The complex web of canonical and non‐canonical Hedgehog signaling
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DOI: 10.1002/bies.202100183
Abstract: Hedgehog (Hh) signaling is a widely studied signaling pathway because of its critical roles during development and in cell homeostasis. Vertebrate canonical and non‐canonical Hh signaling are typically assumed to be distinct and occur in… read more here.
Keywords: hedgehog signaling; canonical non; non canonical; complex web ... See more keywords
Ulipristal acetate decreases active TGF-β3 and its canonical signaling in uterine leiomyoma via two novel mechanisms.
Sign Up to like & getrecommendations! Published in 2019 at "Fertility and sterility"
DOI: 10.1016/j.fertnstert.2018.12.026
Abstract: OBJECTIVE To characterize the effect of ulipristal acetate (UPA) treatment on transforming growth factor (TGF) canonical and noncanonical signaling pathways in uterine leiomyoma tissue and cells. UPA decreased extracellular matrix in surgical specimens; we characterize… read more here.
Keywords: active tgf; canonical signaling; tgf canonical; ulipristal acetate ... See more keywords
A dual role for hepatocyte-intrinsic canonical NF-κB signaling in virus control.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2019.12.019
Abstract: BACKGROUND & AIMS Hepatic innate immune control of viral infections has largely been attributed to Kupffer cells, the liver macrophages. However, also hepatocytes, the parenchymal cells of the liver, possess potent immunological functions in addition… read more here.
Keywords: hepatocyte intrinsic; canonical signaling; role hepatocyte; role ... See more keywords
mGlu1 receptor canonical signaling pathway contributes to the opening of the orphan GluD2 receptor
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DOI: 10.1016/j.neuropharm.2016.06.001
Abstract: &NA; The orphan Glutamate receptor Delta2 (GluD2) intrinsic ion channel activity is indirectly triggered by glutamate through stimulation of the metabotropic glutamate receptor 1 (mGlu1), in cerebellar Purkinje cells. However, the mechanisms of GluD2 ion… read more here.
Keywords: mglu1; canonical signaling; glud2; glud2 channels ... See more keywords
Intestinal non-canonical NFκB signaling shapes the local and systemic immune response
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DOI: 10.1038/s41467-019-08581-8
Abstract: Microfold cells (M-cells) are specialized cells of the intestine that sample luminal microbiota and dietary antigens to educate the immune cells of the intestinal lymphoid follicles. The function of M-cells in systemic inflammatory responses are… read more here.
Keywords: canonical signaling; intestinal non; non canonical; local systemic ... See more keywords
Association of TGF-β Canonical Signaling-Related Core Genes With Aortic Aneurysms and Aortic Dissections
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.888563
Abstract: Transforming growth factor-beta (TGF-β) signaling is essential for the maintenance of the normal structure and function of the aorta. It includes SMAD-dependent canonical pathways and noncanonical signaling pathways. Accumulated genetic evidence has shown that TGF-β… read more here.
Keywords: aortic aneurysms; tgf canonical; aortic dissections; signaling related ... See more keywords
Progress and Prospects of Non-Canonical NF-κB Signaling Pathway in the Regulation of Liver Diseases
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DOI: 10.3390/molecules27134275
Abstract: Non-canonical nuclear factor kappa B (NF-κB) signaling pathway regulates many physiological and pathological processes, including liver homeostasis and diseases. Recent studies demonstrate that non-canonical NF-κB signaling pathway plays an essential role in hyperglycemia, non-alcoholic fatty… read more here.
Keywords: non canonical; canonical signaling; regulation liver; signaling pathway ... See more keywords