Loss of p14 diminishes immunogenicity in melanoma via non‐canonical Wnt signaling by reducing the peptide surface density
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13660
Abstract: Immunotherapy has achieved tremendous success in melanoma. However, only around 50% of advanced melanoma patients benefit from immunotherapy. Cyclin‐dependent kinase inhibitor 2A (CDKN2A), encoding the two tumor‐suppressor proteins p14ARF and p16INK4a, belongs to the most… read more here.
Keywords: surface density; canonical wnt; peptide surface; melanoma ... See more keywords
Characterization and impact of non‐canonical WNT signaling on outcomes of urothelial carcinoma
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DOI: 10.1002/cam4.7148
Abstract: Non‐canonical WNT family (WNT5A pathway) signaling via WNT5A through ROR1 and its partner, ROR2, or Frizzled2 (FZD2) is linked to processes driving tumorigenesis and therapy resistance. We utilized a large dataset of urothelial carcinoma (UC)… read more here.
Keywords: urothelial carcinoma; canonical wnt; non canonical; wnt signaling ... See more keywords
HDAC8 regulates canonical Wnt pathway to promote differentiation in skeletal muscles
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27341
Abstract: Histone deacetylase 8 (HDAC8) is a class 1 histone deacetylase and a member of the cohesin complex. HDAC8 is expressed in smooth muscles, but its expression in skeletal muscle has not been described. We have… read more here.
Keywords: muscle; hdac8; canonical wnt; skeletal muscles ... See more keywords
Canonical Wnt/β-catenin signaling has positive effects on osteogenesis, but can have negative effects on cementogenesis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of periodontology"
DOI: 10.1002/jper.21-0599
Abstract: BACKGROUND To date, therapeutic approaches for cementum regeneration are limited and outcomes remain unpredictable. A significant barrier to improve therapies for cementum regeneration is that the cementocyte and its intracellular signal transduction mechanisms remain poorly… read more here.
Keywords: canonical wnt; idg sw3; wnt catenin; idg ... See more keywords
N‐(3‐methoxybenzyl)‐(9Z,12Z,15Z)‐octadecatrienamide promotes bone formation via the canonical Wnt/β‐catenin signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Phytotherapy Research"
DOI: 10.1002/ptr.6301
Abstract: Osteoporosis is characterized by low bone mineral density and microarchitectural deterioration of bone tissue. N‐(3‐methoxybenzyl)‐(9Z,12Z,15Z)‐octadecatrienamide (MBOC) is one of the macamides isolated from Maca (Lepidium meyenii Walp.), a cruciferous plant from the Andes of Peru.… read more here.
Keywords: 12z 15z; canonical wnt; methoxybenzyl 12z; mboc ... See more keywords
Graphene oxide induces canonical Wnt/β-catenin signaling-dependent toxicity in Caenorhabditis elegans
Sign Up to like & getrecommendations! Published in 2017 at "Carbon"
DOI: 10.1016/j.carbon.2016.11.041
Abstract: The potential adverse effects of graphene oxide (GO) on organisms have received great attention. However, the underlying molecular mechanisms for response to GO exposure are still largely unclear. Canonical Wnt/β-catenin signaling is an evolutionarily conserved… read more here.
Keywords: catenin signaling; catenin; canonical wnt; toxicity ... See more keywords
Response of canonical Wnt/β-catenin signaling pathway in the intestine to microgravity stress in Caenorhabditis elegans.
Sign Up to like & getrecommendations! Published in 2019 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2019.109782
Abstract: Considering the short life-cycle property, Caenorhabditis elegans is a suitable animal model to evaluate the long-term effects of microgravity stress on organisms. Canonical Wnt/β-catenin signaling is evolutionarily conserved in various organisms. We here investigated the… read more here.
Keywords: catenin signaling; catenin; canonical wnt; microgravity ... See more keywords
Premise and peril of Wnt signaling activation through GSK-3β inhibition
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DOI: 10.1016/j.isci.2022.104159
Abstract: Summary Wnt signaling pathways have been extensively studied in the context of several diseases, including cancer, coronary artery disease, and age-related disorders. β-Catenin plays a central role in the most studied Wnt pathways, the Wnt/β-catenin… read more here.
Keywords: gsk; canonical wnt; wnt; chir 99021 ... See more keywords
3, 3', 5-Triiodo-L-thyronine affects polarity proteins of bovine Sertoli cells via WT1/non-canonical Wnt signaling pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Theriogenology"
DOI: 10.1016/j.theriogenology.2020.02.034
Abstract: To determine the role of 3, 3', 5-triiodo-L thyroxine (T3) in the differentiation of Sertoli cells (SCs) and the factors influencing maturity via the Wilms' tumor 1 (WT1)/non-canonical Wnt signaling pathway, high purity SCs were… read more here.
Keywords: wnt signaling; wnt; canonical wnt; wt1 non ... See more keywords
Canonical Wnt signaling regulates patterning, differentiation and nucleogenesis in mouse hypothalamus and prethalamus.
Sign Up to like & getrecommendations! Published in 2018 at "Developmental biology"
DOI: 10.1016/j.ydbio.2018.07.021
Abstract: The hypothalamus is a small, but anatomically and functionally complex region of the brain whose development is poorly understood. In this study, we have explored its development by studying the canonical Wnt signaling pathway, generating… read more here.
Keywords: wnt signaling; hypothalamus; canonical wnt; differentiation ... See more keywords
Deletion of the Dishevelled family of genes disrupts anterior-posterior axis specification and selectively prevents mesoderm differentiation.
Sign Up to like & getrecommendations! Published in 2020 at "Developmental biology"
DOI: 10.1016/j.ydbio.2020.05.010
Abstract: The Dishevelled proteins transduce both canonical Wnt/β-catenin and non-canonical Wnt/planar cell polarity (PCP) signaling pathways to regulate many key developmental processes during embryogenesis. Here, we disrupt both canonical and non-canonical Wnt pathways by targeting the… read more here.
Keywords: dvl tko; canonical wnt; axis specification; differentiation ... See more keywords