Efficacy and safety of two dosages of canrenone as add‐on therapy in hypertensive patients taking ace‐inhibitors or angiotensin II receptor blockers and hydrochlorothiazide at maximum dosage in a randomized clinical trial: The ESCAPE‐IT trial
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DOI: 10.1111/1755-5922.12235
Abstract: Summary Aim To evaluate the effects of canrenone as add‐on therapy in patients already treated with angiotensin‐converting enzyme inhibitors (ACE‐I) or angiotensin II receptor blockers (ARBs) and hydrochlorothiazide at the maximum dosage (25 mg/d). Method… read more here.
Keywords: canrenone; trial; canrenone add; add therapy ... See more keywords
Clinical efficacy of potassium canreonate-canrenone in sinus rhythm restoration among patients with atrial fibrillation - a protocol of a pilot, randomized, double -blind, placebo-controlled study (CANREN-AF trial)
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DOI: 10.1186/s13063-020-04277-3
Abstract: Background Atrial fibrillation (AF) is the most frequent cardiac arrhythmia which increases the risk of thromboembolic complications and impairs quality of life. An important part of a therapeutic approach for AF is sinus rhythm restoration.… read more here.
Keywords: canrenone; rhythm restoration; efficacy; sinus rhythm ... See more keywords
Canrenone Restores Vasorelaxation Impaired by Marinobufagenin in Human Preeclampsia
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DOI: 10.3390/ijms23063336
Abstract: Previous studies implicated cardiotonic steroids, including Na/K-ATPase inhibitor marinobufagenin (MBG), in the pathogenesis of preeclampsia (PE). Recently, we demonstrated that (i) MBG induces fibrosis in rat tissues via a mechanism involving Fli1, a negative regulator… read more here.
Keywords: umbilical arteries; canrenone; mbg level; preeclampsia ... See more keywords