HPLC-UV-based simultaneous determination of canthin-6-one alkaloids, quassinoids,and scopoletin: the active ingredients in Eurycoma Longifolia Jack and Eurycoma Harmandiana Pierre, and their anti-inflammatory activities.
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DOI: 10.1093/jaoacint/qsaa141
Abstract: BACKGROUND Quassinoids and canthin-6-one alkaloids are bioactive markers of Eurycoma longifolia (EL) and E. harmandiana (EH) and have been commercially utilized to treat inflammation and male infertility. OBJECTIVES This study aims to reveal the contents… read more here.
Keywords: anti inflammatory; quassinoids scopoletin; alkaloids quassinoids; one alkaloids ... See more keywords
Quantitative proteomics reveals the antifungal effect of canthin-6-one isolated from Ailanthus altissima against Fusarium oxysporum f. sp. cucumerinum in vitro
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DOI: 10.1371/journal.pone.0250712
Abstract: Canthin-6-one, one of the main alkaloid compounds extracted from Ailanthus altissima, has recently attracted increasing interest for its antifungal activity. To evaluate the potential of canthin-6-one in controlling plant fungal diseases, we investigated the antifungal… read more here.
Keywords: fusarium oxysporum; ailanthus altissima; one isolated; altissima fusarium ... See more keywords
Canthin-6-One Accelerates Alpha-Synuclein Degradation by Enhancing UPS Activity: Drug Target Identification by CRISPR-Cas9 Whole Genome-Wide Screening Technology
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DOI: 10.3389/fphar.2019.00016
Abstract: Parkinson’s disease (PD) is the second most common neurodegenerative disorder characterized by the accumulation of protein aggregates (namely Lewy bodies) in dopaminergic neurons in the substantia nigra region of the brain. Alpha-synuclein (α-syn) is the… read more here.
Keywords: genome wide; crispr cas9; screening technology; canthin one ... See more keywords