Isoxazole-containing 5' mRNA cap analogues as inhibitors of the translation initiation process.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.103583
Abstract: Herein we describe a synthesis of new isoxazole-containing 5' mRNA cap analogues via a cycloaddition reaction. The obtained analogues show a capability to inhibit cap-dependent translation in vitro and are characterized by a new binding… read more here.
Keywords: isoxazole containing; mrna cap; containing mrna; cap analogues ... See more keywords
Decapping Scavenger Enzyme Activity toward N2-Substituted 5′ End mRNA Cap Analogues
Sign Up to like & getrecommendations! Published in 2019 at "ACS Omega"
DOI: 10.1021/acsomega.9b02715
Abstract: mRNA degradation is a key mechanism of gene expression regulation. In the 3′ → 5′ decay pathway, mRNA is degraded by the exosome complex and the resulting cap dinucleotide or short-capped oligonucleotide is hydrolyzed mainly… read more here.
Keywords: scavenger enzyme; cap analogues; activity; cap ... See more keywords