4EGI-1 represses cap-dependent translation and regulates genome-wide translation in malignant pleural mesothelioma
Sign Up to like & getrecommendations! Published in 2017 at "Investigational New Drugs"
DOI: 10.1007/s10637-017-0535-z
Abstract: SummaryDeregulation of cap-dependent translation has been implicated in the malignant transformation of numerous human tissues. 4EGI-1, a novel small-molecule inhibitor of cap-dependent translation, disrupts formation of the eukaryotic initiation factor 4F (eIF4F) complex. The effects… read more here.
Keywords: genome wide; dependent translation; pleural mesothelioma; malignant pleural ... See more keywords
Eukaryotic initiation factor 4E is a novel effector of mTORC1 signaling pathway in cross talk with Mnk1
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-019-03663-z
Abstract: Cellular signals that influence Cap-dependent translation have assumed significant relevance in the backdrop of their enforced dysregulation during oncogenesis. Eukaryotic initiation factor 4E(eIF4E), the mRNA cap-binding protein, has emerged as a key player to facilitate… read more here.
Keywords: initiation factor; phosphorylation; eukaryotic initiation; cap dependent ... See more keywords
Discovery of Novel Thiophene-Based Baloxavir Derivatives as Potent Cap-Dependent Endonuclease Inhibitors for Influenza Treatment.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.4c01979
Abstract: The genetic recombination and antigenic variation of influenza viruses may decrease the efficacy of antiviral vaccines, highlighting the imperativeness of developing novel anti-influenza agents. Herein, a series of thiophene-based compounds were designed and synthesized as… read more here.
Keywords: dependent endonuclease; cap dependent; anti influenza; thiophene based ... See more keywords
Inhibition of oncogenic cap-dependent translation by 4EGI-1 reduces growth, enhances chemosensitivity and alters genome-wide translation in non-small cell lung cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Gene Therapy"
DOI: 10.1038/s41417-018-0058-6
Abstract: Hyperactivation of eIF4F-mediated translation occurs in many if not all cancers. As a consequence, cancer cells aberrantly enhance expression of malignancy-related proteins that are involved in cell cycle progression, angiogenesis, growth, and proliferation. With this… read more here.
Keywords: translation; non small; cancer; cell ... See more keywords
Molecular Dynamics Simulation reveals the mechanism by which the Influenza Cap-dependent Endonuclease acquires resistance against Baloxavir marboxil
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-53945-1
Abstract: Baloxavir marboxil (BXM), an antiviral drug for influenza virus, inhibits RNA replication by binding to RNA replication cap-dependent endonuclease (CEN) of influenza A and B viruses. Although this drug was only approved by the FDA… read more here.
Keywords: molecular dynamics; dependent endonuclease; simulation; baloxavir marboxil ... See more keywords
Identification of cap-dependent endonuclease inhibitors with broad-spectrum activity against bunyaviruses
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2206104119
Abstract: Significance Bunyaviruses, like influenza viruses, possess a cap-dependent endonuclease (CEN) that mediates the critical cap-snatching step of viral RNA transcription. We identified the antibunyavirus compounds among influenza CEN inhibitors and identified specific structures involved in… read more here.
Keywords: identification cap; cap dependent; cap; dependent endonuclease ... See more keywords
The diversity, plasticity, and adaptability of cap-dependent translation initiation and the associated machinery
Sign Up to like & getrecommendations! Published in 2020 at "RNA Biology"
DOI: 10.1080/15476286.2020.1766179
Abstract: ABSTRACT Translation initiation is a critical facet of gene expression with important impacts that underlie cellular responses to stresses and environmental cues. Its dysregulation in many diseases position this process as an important area for… read more here.
Keywords: translation initiation; translation; dependent translation; cap dependent ... See more keywords
IDH1 fine-tunes cap-dependent translation initiation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Cell Biology"
DOI: 10.1093/jmcb/mjz082
Abstract: Abstract The metabolic enzyme isocitrate dehydrogenase 1 (IDH1) catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate (α-KG). Its mutation often leads to aberrant gene expression in cancer. IDH1 was reported to bind thousands of RNA… read more here.
Keywords: dependent translation; translation initiation; idh1 fine; idh1 ... See more keywords
A cap 0-dependent mRNA capture method to analyze the yeast transcriptome
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac903
Abstract: Abstract Analysis of the protein coding transcriptome by the RNA sequencing requires either enrichment of the desired fraction of coding transcripts or depletion of the abundant non-coding fraction consisting mainly of rRNA. We propose an… read more here.
Keywords: dependent mrna; method; mrna; cap dependent ... See more keywords
A cap-dependent endonuclease inhibitor acts as a potent antiviral agent against La Crosse virus infection
Sign Up to like & getrecommendations! Published in 2025 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00186-25
Abstract: ABSTRACT La Crosse virus (LACV) infection, the causative agent of La Crosse encephalitis, can lead to severe neurological symptoms and sequelae, particularly in children. Despite annual reports of neurologically symptomatic cases, no effective treatment has… read more here.
Keywords: crosse; cap dependent; infection; crosse virus ... See more keywords
Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy.
Sign Up to like & getrecommendations! Published in 2025 at "Cancer research"
DOI: 10.1158/0008-5472.can-24-3420
Abstract: Cancers co-opt stress response pathways to drive oncogenesis, dodge immune surveillance, and resist cytotoxic therapies. Several of these pathways also provide protection from ferroptosis, an iron-dependent oxidative cell death pathway triggered by clinically available drugs… read more here.
Keywords: initiation; cap dependent; car; ferroptosis ... See more keywords