The cap epitranscriptome: Early directions to a complex life as mRNA
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202200198
Abstract: Animal, protist and viral messenger RNAs (mRNAs) are most prominently modified at the beginning by methylation of cap‐adjacent nucleotides at the 2′‐O‐position of the ribose (cOMe) by dedicated cap methyltransferases (CMTrs). If the first nucleotide… read more here.
Keywords: epitranscriptome early; cap epitranscriptome; gene expression; cap ... See more keywords
Quantifying the RNA cap epitranscriptome reveals novel caps in cellular and viral RNA
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz751
Abstract: Abstract Chemical modification of transcripts with 5′ caps occurs in all organisms. Here, we report a systems-level mass spectrometry-based technique, CapQuant, for quantitative analysis of an organism's cap epitranscriptome. The method was piloted with 21… read more here.
Keywords: cap; epitranscriptome reveals; rna cap; rna ... See more keywords