Diketo acids inhibit the cap-snatching endonuclease of several Bunyavirales.
Sign Up to like & getrecommendations! Published in 2020 at "Antiviral research"
DOI: 10.1016/j.antiviral.2020.104947
Abstract: Several fatal bunyavirus infections lack specific treatment. Here, we show that diketo acids engage a panel of bunyavirus cap-snatching endonucleases, inhibit their catalytic activity and reduce viral replication of a taxonomic representative in vitro. Specifically,… read more here.
Keywords: diketo acids; endonuclease several; inhibit cap; acids inhibit ... See more keywords
Cap-Snatching Leads to Novel Viral Proteins
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DOI: 10.1016/j.cell.2020.05.044
Abstract: Some negative-sense RNA viruses prime mRNA transcription using host 5' cap sequences, usurping host translational machinery and evading antiviral surveillance. In this issue of Cell, Ho et al. identify an additional consequence of this viral strategy:… read more here.
Keywords: leads novel; novel viral; snatching leads; cap snatching ... See more keywords
Interplay between Influenza Virus and the Host RNA Polymerase II Transcriptional Machinery
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DOI: 10.1016/j.tim.2018.12.013
Abstract: The influenza virus RNA-dependent RNA polymerase (RdRP) cleaves the 5′ end of nascent capped host RNAs and uses the capped RNA fragment to prime viral transcription in a mechanism called ‘cap snatching’. Cap snatching requires… read more here.
Keywords: influenza; rna polymerase; host; cap snatching ... See more keywords
Structure and function of the Toscana virus cap-snatching endonuclease
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz838
Abstract: Abstract Toscana virus (TOSV) is an arthropod-borne human pathogen responsible for seasonal outbreaks of fever and meningoencephalitis in the Mediterranean basin. TOSV is a segmented negative-strand RNA virus (sNSV) that belongs to the genus phlebovirus… read more here.
Keywords: structure; toscana virus; snatching endonuclease; cap snatching ... See more keywords
Structural and Biochemical Basis for Development of Diketo Acid Inhibitors Targeting the Cap-Snatching Endonuclease of the Ebinur Lake Virus (Order: Bunyavirales)
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.02173-21
Abstract: The Bunyavirales contain many important human pathogens such as Crimean-Congo hemorrhagic fever virus and Lassa virus that pose serious threats to public health; however, currently there are no specific antiviral drugs against these viruses. The… read more here.
Keywords: 742 001; cap snatching; virus; snatching endonuclease ... See more keywords
Influenza A virus utilizes non-canonical cap-snatching to diversify its mRNA/ncRNA.
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DOI: 10.1261/rna.073866.119
Abstract: Influenza A virus (IAV) utilizes cap-snatching to obtain host capped small RNAs for priming viral mRNA synthesis, generating capped hybrid mRNAs for translation. Previous studies have been focusing on canonical cap-snatching, which occurs at the… read more here.
Keywords: canonical cap; snatching diversify; non canonical; cap snatching ... See more keywords
Bunyaviral N Proteins Localize at RNA Processing Bodies and Stress Granules: The Enigma of Cytoplasmic Sources of Capped RNA for Cap Snatching
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DOI: 10.3390/v14081679
Abstract: Most cytoplasmic-replicating negative-strand RNA viruses (NSVs) initiate genome transcription by cap snatching. The source of host mRNAs from which the cytoplasmic NSVs snatch capped-RNA leader sequences has remained elusive. Earlier reports have pointed towards cytoplasmic-RNA… read more here.
Keywords: capped rna; cap; rna processing; processing bodies ... See more keywords