Capping protein regulator and myosin 1 linker 3 regulates transcription of key cytokines in activated phagocytic cells.
Sign Up to like & getrecommendations! Published in 2020 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2020.109848
Abstract: We have recently reported that capping protein regulator and myosin 1 linker 3 (CARMIL3), first identified as an oncofetal-like gene, is required for metastasis of breast and prostate cancer cells via regulating the actin cytoskeletal… read more here.
Keywords: protein; carmil3; capping protein; regulator myosin ... See more keywords
Structural insights into the regulation of actin capping protein by twinfilin C-terminal tail.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2021.166891
Abstract: Twinfilin is a conserved actin regulator that interacts with actin capping protein (CP) via C-terminus residues (TWtail) that exhibits sequence similarity with the CP interaction (CPI) motif of CARMIL. Here we report the crystal structure… read more here.
Keywords: actin capping; capping protein; structural insights; carmil cpi ... See more keywords
Comparative analysis of CPI-motif regulation of biochemical functions of actin capping protein.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemistry"
DOI: 10.1021/acs.biochem.0c00092
Abstract: The heterodimeric actin capping protein (CP) is regulated by a set of proteins that contain CP-interacting (CPI) motifs. Outside of the CPI motif, the sequences of these proteins are unrelated and distinct. The CPI motif… read more here.
Keywords: cpi; cpi motif; actin capping; capping protein ... See more keywords
A barbed end interference mechanism reveals how capping protein promotes nucleation in branched actin networks
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-25682-5
Abstract: Heterodimeric capping protein (CP/CapZ) is an essential factor for the assembly of branched actin networks, which push against cellular membranes to drive a large variety of cellular processes. Aside from terminating filament growth, CP potentiates… read more here.
Keywords: capping protein; actin; branched actin; nucleation branched ... See more keywords
The actin capping protein in Aspergillus nidulans enhances dynein function without significantly affecting Arp1 filament assembly
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-29818-4
Abstract: The minus-end-directed microtubule motor cytoplasmic dynein requires the dynactin complex for in vivo functions. The backbone of the vertebrate dynactin complex is the Arp1 (actin-related protein 1) mini-filament whose barbed end binds to the heterodimeric… read more here.
Keywords: capping protein; arp1 filament; protein; dynactin complex ... See more keywords
Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cancer Research"
DOI: 10.1158/1541-7786.mcr-19-0722
Abstract: Metastasis accounts for 90% of deaths caused by solid tumors, but the multitude of mechanisms underlying tumor metastasis remains poorly understood. CARMIL1 and 2 proteins are capping protein (CP) interactants and multidomain regulators of actin-based… read more here.
Keywords: expression; metastasis; tumor metastasis; carmil3 ... See more keywords
Dual regulation of the actin cytoskeleton by CARMIL-GAP
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cell Science"
DOI: 10.1242/jcs.258704
Abstract: CARMIL (Capping protein Arp2/3 Myosin I Linker) proteins are multi-domain scaffold proteins that regulate actin dynamics by regulating the activity of Capping Protein (CP). Here we characterize CARMIL-GAP, a Dictyostelium CARMIL isoform that contains a… read more here.
Keywords: carmil gap; rho; gap domain; capping protein ... See more keywords
Dia- and Rok-dependent enrichment of capping proteins in a cortical region.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cell science"
DOI: 10.1242/jcs.258973
Abstract: Rho signaling with its major targets the formin Dia, Rho kinase (Rok) and non-muscle myosin II control turnover, amount and contractility of actomyosin. Much less investigated has been a potential function for the distribution of… read more here.
Keywords: capping protein; dia rok; capping proteins; rok ... See more keywords
Functional requirements for a Samd14-capping protein complex in stress erythropoiesis
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.76497
Abstract: Acute anemia induces rapid expansion of erythroid precursors and accelerated differentiation to replenish erythrocytes. Paracrine signals – involving cooperation between SCF/c-Kit signaling and other signaling inputs – are required for the increased erythroid precursor activity… read more here.
Keywords: protein complex; stress; kit signaling; capping protein ... See more keywords