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Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.641
Abstract: The capsaicin receptor, TRPV1 ion channel, is a polymodal nociceptor and attractive drug target. Recent advances in cryo-electron microscopy revealed the vanilloid-binding pocket in high resolution, which allowed atomic interactions mediating capsaicin binding to be…
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Keywords:
trpv1;
capsaicin;
vanilloid;
capsaicin binding ... See more keywords
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Published in 2022 at "Journal of Chemical Information and Modeling"
DOI: 10.1021/acs.jcim.1c01441
Abstract: Transient receptor potential (TRP) ion channels are important pharmacological targets because of their role in the perception of pain, and so, understanding their chemical regulation is essential for the development of analgesic drugs. Among the…
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Keywords:
binding site;
capsaicin binding;
ion;
channel ... See more keywords