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   Articles with "capsid assembly" as a keyword



Drug‐Drug Interactions With the Hepatitis B Virus Capsid Assembly Modulator JNJ‐56136379 (Bersacapavir)

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recommendations! Published in 2022 at "Clinical Pharmacology in Drug Development"

DOI: 10.1002/cpdd.1164

Abstract: The capsid assembly modulator JNJ‐56136379 (bersacapavir) disrupts hepatitis B virus replication. It is metabolized via cytochrome P450 (CYP) 3A, but little is known about the drug‐drug interactions of JNJ‐56136379 when combined with drugs that inhibit… read more here.

Keywords: assembly modulator; capsid assembly; jnj 56136379; modulator jnj ... See more keywords

An in silico study to unveil potential drugs and vaccine chimera for HBV capsid assembly protein: combined molecular docking and dynamics simulation approach

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recommendations! Published in 2022 at "Journal of Molecular Modeling"

DOI: 10.1007/s00894-022-05042-w

Abstract: Humans are a major reservoir of the hepatitis B virus (HBV), therefore promising treatment and control vaccination strategies are needed to eradicate the virus. Though promising drugs and vaccines are available against HBV, still efforts… read more here.

Keywords: vaccine chimera; capsid assembly; drug; assembly protein ... See more keywords
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Molecular dynamics study of T = 3 capsid assembly

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recommendations! Published in 2018 at "Journal of Biological Physics"

DOI: 10.1007/s10867-018-9486-7

Abstract: Molecular dynamics simulation is used to model the self-assembly of polyhedral shells containing 180 trapezoidal particles that correspond to the T = 3 virus capsid. Three kinds of particle, differing only slightly in shape, are… read more here.

Keywords: study capsid; dynamics study; molecular dynamics; capsid assembly ... See more keywords

Pharmacokinetics, Safety and Tolerability of JNJ-56136379, a Novel Hepatitis B Virus Capsid Assembly Modulator, in Healthy Subjects

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recommendations! Published in 2019 at "Advances in Therapy"

DOI: 10.1007/s12325-019-01017-1

Abstract: IntroductionHepatitis B viral capsid assembly is an attractive target for new antiviral treatments. JNJ-56136379 (JNJ-6379) is a potent capsid assembly modulator in vitro with a dual mode of action. In Part 1 of this first-in-human… read more here.

Keywords: jnj 56136379; jnj; capsid assembly; safety ... See more keywords

5-Aminothiophene-2,4-dicarboxamide analogues as hepatitis B virus capsid assembly effectors.

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recommendations! Published in 2019 at "European journal of medicinal chemistry"

DOI: 10.1016/j.ejmech.2018.12.047

Abstract: Chronic hepatitis B virus (HBV) infection represents a major health threat. Current FDA-approved drugs do not cure HBV. Targeting HBV core protein (Cp) provides an attractive approach toward HBV inhibition and possibly infection cure. We… read more here.

Keywords: capsid assembly; chemistry; hepatitis virus; assembly effectors ... See more keywords

Label-Free Tracking of Hepatitis B Virus Core Protein Capsid Assembly in Real-Time Using Protein Charge Transfer Spectra.

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recommendations! Published in 2024 at "Biomacromolecules"

DOI: 10.1021/acs.biomac.4c00521

Abstract: Hepatitis B virions are double-shelled particles, with a diameter of 40-42 nm, consisting of a nucleocapsid called the HBV core protein (HBV Cp). It is an ordered assembly of 90-120 homodimers arranged in an icosahedral… read more here.

Keywords: capsid; real time; time; capsid assembly ... See more keywords

The Mechanism of Action of Hepatitis B Virus Capsid Assembly Modulators Can Be Predicted from Binding to Early Assembly Intermediates.

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recommendations! Published in 2022 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.1c02040

Abstract: Interfering with the self-assembly of virus nucleocapsids is a promising approach for the development of novel antiviral agents. Applied to hepatitis B virus (HBV), this approach has led to several classes of capsid assembly modulators… read more here.

Keywords: assembly modulators; assembly intermediates; capsid assembly; hepatitis virus ... See more keywords

The Discovery and Preclinical Profile of ALG-000184, a Prodrug of the Potent Hepatitis B Virus Capsid Assembly Modulator ALG-001075.

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recommendations! Published in 2024 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.4c01814

Abstract: Chronic hepatitis B (CHB) represents a significant unmet medical need with few options beyond lifelong treatment with nucleoside analogues, which rarely leads to a functional cure. Novel agents that reduce levels of HBV DNA, RNA… read more here.

Keywords: capsid assembly; alg 001075; hepatitis; alg 000184 ... See more keywords

Biophysics-Guided Lead Discovery of HBV Capsid Assembly Modifiers

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recommendations! Published in 2024 at "ACS Infectious Diseases"

DOI: 10.1021/acsinfecdis.3c00479

Abstract: Hepatitis B virus (HBV) is the leading cause of chronic liver pathologies worldwide. HBV nucleocapsid, a key structural component, is formed through the self-assembly of the capsid protein units. Therefore, interfering with the self-assembly process… read more here.

Keywords: biophysics; hbv; biophysics guided; capsid assembly ... See more keywords

Discovery of VNRX-9945, a Potent, Broadly Active Capsid Assembly Modulator as a Clinical Candidate for the Treatment of Chronic Hepatitis B Virus Infection.

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recommendations! Published in 2025 at "ACS medicinal chemistry letters"

DOI: 10.1021/acsmedchemlett.5c00315

Abstract: Targeting the capsid protein of the hepatitis B virus (HBV) has emerged as a promising strategy for developing new antiviral therapies. In this study, we report the discovery of a novel series of pyrrole oxo-carboxamide… read more here.

Keywords: hbv; capsid; hepatitis virus; capsid assembly ... See more keywords

Capsid structure of bacteriophage ΦKZ provides insights into assembly and stabilization of jumbo phages

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recommendations! Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-024-50811-1

Abstract: Jumbo phages are a group of tailed bacteriophages with large genomes and capsids. As a prototype of jumbo phage, ΦKZ infects Pseudomonas aeruginosa, a multi-drug-resistant (MDR) opportunistic pathogen leading to acute or chronic infection in… read more here.

Keywords: assembly stabilization; capsid structure; capsid; capsid assembly ... See more keywords