Drug‐Drug Interactions With the Hepatitis B Virus Capsid Assembly Modulator JNJ‐56136379 (Bersacapavir)
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DOI: 10.1002/cpdd.1164
Abstract: The capsid assembly modulator JNJ‐56136379 (bersacapavir) disrupts hepatitis B virus replication. It is metabolized via cytochrome P450 (CYP) 3A, but little is known about the drug‐drug interactions of JNJ‐56136379 when combined with drugs that inhibit… read more here.
Keywords: assembly modulator; capsid assembly; jnj 56136379; modulator jnj ... See more keywords
An in silico study to unveil potential drugs and vaccine chimera for HBV capsid assembly protein: combined molecular docking and dynamics simulation approach
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Molecular Modeling"
DOI: 10.1007/s00894-022-05042-w
Abstract: Humans are a major reservoir of the hepatitis B virus (HBV), therefore promising treatment and control vaccination strategies are needed to eradicate the virus. Though promising drugs and vaccines are available against HBV, still efforts… read more here.
Keywords: vaccine chimera; capsid assembly; drug; assembly protein ... See more keywords
Molecular dynamics study of T = 3 capsid assembly
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DOI: 10.1007/s10867-018-9486-7
Abstract: Molecular dynamics simulation is used to model the self-assembly of polyhedral shells containing 180 trapezoidal particles that correspond to the T = 3 virus capsid. Three kinds of particle, differing only slightly in shape, are… read more here.
Keywords: study capsid; dynamics study; molecular dynamics; capsid assembly ... See more keywords
Pharmacokinetics, Safety and Tolerability of JNJ-56136379, a Novel Hepatitis B Virus Capsid Assembly Modulator, in Healthy Subjects
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DOI: 10.1007/s12325-019-01017-1
Abstract: IntroductionHepatitis B viral capsid assembly is an attractive target for new antiviral treatments. JNJ-56136379 (JNJ-6379) is a potent capsid assembly modulator in vitro with a dual mode of action. In Part 1 of this first-in-human… read more here.
Keywords: jnj 56136379; jnj; capsid assembly; safety ... See more keywords
5-Aminothiophene-2,4-dicarboxamide analogues as hepatitis B virus capsid assembly effectors.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.12.047
Abstract: Chronic hepatitis B virus (HBV) infection represents a major health threat. Current FDA-approved drugs do not cure HBV. Targeting HBV core protein (Cp) provides an attractive approach toward HBV inhibition and possibly infection cure. We… read more here.
Keywords: capsid assembly; chemistry; hepatitis virus; assembly effectors ... See more keywords
The Mechanism of Action of Hepatitis B Virus Capsid Assembly Modulators Can Be Predicted from Binding to Early Assembly Intermediates.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c02040
Abstract: Interfering with the self-assembly of virus nucleocapsids is a promising approach for the development of novel antiviral agents. Applied to hepatitis B virus (HBV), this approach has led to several classes of capsid assembly modulators… read more here.
Keywords: assembly modulators; assembly intermediates; capsid assembly; hepatitis virus ... See more keywords
A Unique Role of the Human Cytomegalovirus Small Capsid Protein in Capsid Assembly
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DOI: 10.1128/mbio.01007-22
Abstract: Human cytomegalovirus (HCMV) is a ubiquitous pathogen causing life-threatening disease in immunocompromised individuals. Virus-specific processes such as capsid assembly and genome packaging can be exploited to design new antiviral strategies. ABSTRACT Morphogenesis of herpesvirus particles… read more here.
Keywords: capsid protein; capsid assembly; hcmv; capsid ... See more keywords
Design and Synthesis of Hepatitis B Virus (HBV) Capsid Assembly Modulators and Evaluation of Their Activity in Mammalian Cell Model
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DOI: 10.3390/ph15070773
Abstract: Capsid assembly modulators (CAMs) have emerged as a promising class of antiviral agents. We studied the effects of twenty-one newly designed and synthesized CAMs including heteroaryldihydropyrimidine compounds (HAPs), their analogs and standard compounds on hepatitis… read more here.
Keywords: hbv capsid; assembly modulators; capsid assembly; capsid ... See more keywords
Structure-Based Discovery of N-Sulfonylpiperidine-3-Carboxamides as Novel Capsid Assembly Modulators for Potent Inhibition of HBV Replication
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DOI: 10.3390/v14020348
Abstract: As a key element during HBV replication, a nucleocapsid is considered a promising target for the treatment of chronic hepatitis B. The present study aimed to identify small molecules as novel capsid assembly modulators with… read more here.
Keywords: assembly modulators; capsid assembly; hbv; capsid ... See more keywords
The SUMOylation of Human Cytomegalovirus Capsid Assembly Protein Precursor (UL80.5) Affects Its Interaction with Major Capsid Protein (UL86) and Viral Replication
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DOI: 10.3390/v15040931
Abstract: Human Cytomegalovirus Capsid Assembly Protein Precursor (pAP, UL80.5) plays a key role in capsid assembly by forming an internal protein scaffold with Major Capsid Protein (MCP, UL86) and other capsid subunits. In this study, we… read more here.
Keywords: capsid assembly; viral replication; sumoylation; capsid ... See more keywords
Mutations in HPV18 E1^E4 Impact Virus Capsid Assembly, Infectivity Competence, and Maturation
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DOI: 10.3390/v9120385
Abstract: The most highly expressed protein during the productive phase of the human papillomavirus (HPV) life cycle is E1^E4. Its full role during infection remains to be established. HPV E1^E4 is expressed during both the early… read more here.
Keywords: capsid assembly; infectivity; maturation; virus ... See more keywords