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   Articles with "capsid inhibitor" as a keyword



Discovery of Lenacapavir: First-in-Class Twice-Yearly Capsid Inhibitor for HIV‑1 Treatment and Pre-exposure Prophylaxis

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recommendations! Published in 2025 at "Journal of Medicinal Chemistry"

DOI: 10.1021/acs.jmedchem.5c01625

Abstract: The HIV capsid is essential to the virus lifecycle, making it a promising target for therapeutic intervention. In 2006, a screening campaign was initiated to identify small molecules capable of disrupting the protein–protein interactions required… read more here.

Keywords: treatment; hiv; capsid inhibitor; twice yearly ... See more keywords

Long-acting capsid inhibitor protects macaques from repeat SHIV challenges

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recommendations! Published in 2021 at "Nature"

DOI: 10.1038/s41586-021-04279-4

Abstract: Because no currently available vaccine can prevent HIV infection, pre-exposure prophylaxis (PrEP) with antiretrovirals (ARVs) is an important tool for combating the HIV pandemic 1 , 2 . Long-acting ARVs promise to build on the… read more here.

Keywords: shiv challenges; capsid inhibitor; hiv; long acting ... See more keywords

Prevalence of Naturally Occurring HIV-1 Capsid Inhibitor Resistance–Related Mutations in Antiretroviral Therapy–Naïve and –Experienced Individuals in Taiwan

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recommendations! Published in 2025 at "Open Forum Infectious Diseases"

DOI: 10.1093/ofid/ofaf028

Abstract: Abstract Background It is generally believed that HIV-1 capsid inhibitor–naïve populations are susceptible to capsid inhibitors. Moreover, conventional HIV-1 resistance genotyping does not include the CA region, leading to limited surveillance data. Methods We conducted… read more here.

Keywords: capsid inhibitor; inhibitor resistance; capsid; hiv ... See more keywords

Natural occurrence of drug resistance mutations to the HIV‐1 capsid inhibitor lenacapavir

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recommendations! Published in 2025 at "HIV Medicine"

DOI: 10.1111/hiv.70092

Abstract: Lenacapavir (LEN) is a first‐in‐class HIV‐1 capsid inhibitor. We investigated the natural occurrence of LEN drug resistance mutations (DRM) in HIV‐1 sequences from LEN treatment‐naïve individuals. read more here.

Keywords: natural occurrence; capsid inhibitor; drug resistance; hiv capsid ... See more keywords