The N-terminal region (VP4) of the foot-and-mouth disease capsid precursor (P1-2A) is not required during its synthesis to allow subsequent processing by the 3C protease.
Sign Up to like & getrecommendations! Published in 2022 at "Virology"
DOI: 10.1016/j.virol.2022.03.006
Abstract: The capsid precursor (P1-2A) of foot-and-mouth disease virus is processed by the 3C protease (3Cpro) to VP0, VP3 and VP1 plus 2A. During capsid assembly, the VP0 is cleaved to VP4 plus VP2. Single amino… read more here.
Keywords: foot mouth; precursor; mouth disease; processing ... See more keywords
Identification of plasticity and interactions of a highly conserved motif within a picornavirus capsid precursor required for virus infectivity
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-48170-9
Abstract: The picornavirus family includes poliovirus (PV) (genus: enterovirus), human rhinoviruses (enterovirus) and foot-and-mouth disease virus (FMDV) (aphthovirus). These are responsible for important human and animal health concerns worldwide including poliomyelitis, the common cold and foot-and-mouth… read more here.
Keywords: capsid; virus infectivity; highly conserved; capsid precursor ... See more keywords
The Capsid Precursor Protein of Astrovirus VA1 Is Proteolytically Processed Intracellularly
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.00665-22
Abstract: Human astrovirus VA1 has been associated with neurological disease in immunocompromised patients. Its recent propagation in cell culture has facilitated the study of its biology. ABSTRACT Human astrovirus VA1 has been associated with neurological disease… read more here.
Keywords: capsid precursor; astrovirus va1; va1; biology ... See more keywords
The Cellular Chaperone Heat Shock Protein 90 Is Required for Foot-and-Mouth Disease Virus Capsid Precursor Processing and Assembly of Capsid Pentamers
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Virology"
DOI: 10.1128/jvi.01415-17
Abstract: ABSTRACT Productive picornavirus infection requires the hijacking of host cell pathways to aid with the different stages of virus entry, synthesis of the viral polyprotein, and viral genome replication. Many picornaviruses, including foot-and-mouth disease virus… read more here.
Keywords: protein; cellular chaperone; formation; capsid precursor ... See more keywords