Discovery of novel 1,2,4‐triazole phenylalanine derivatives targeting an unexplored region within the interprotomer pocket of the HIV capsid protein
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28064
Abstract: Human immunodeficiency virus (HIV) capsid (CA) protein is a promising target for developing novel anti‐HIV drugs. Starting from highly anticipated CA inhibitors PF‐74, we used scaffold hopping strategy to design a series of novel 1,2,4‐triazole… read more here.
Keywords: capsid protein; novel triazole; hiv; hiv capsid ... See more keywords
SERTAD3 induces proteasomal degradation of ZIKV capsid protein and represents a therapeutic target
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28451
Abstract: Zika virus (ZIKV) is a mosquito‐borne RNA virus that belongs to the Flaviviridae family. While flavivirus replication is known to occur in the cytoplasm, a significant portion of the viral capsid protein localizes to the… read more here.
Keywords: capsid protein; zikv; capsid; proteasomal degradation ... See more keywords
A broadly cross-reactive monoclonal antibody against hepatitis E virus capsid antigen
Sign Up to like & getrecommendations! Published in 2021 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-021-11342-7
Abstract: Abstract To generate a hepatitis E virus (HEV) genotype 3 (HEV-3)–specific monoclonal antibody (mAb), the Escherichia coli–expressed carboxy-terminal part of its capsid protein was used to immunise BALB/c mice. The immunisation resulted in the induction… read more here.
Keywords: antibody; capsid protein; hev; capsid ... See more keywords
Identification of novel B-cell epitopes on the capsid protein of type 1 porcine astrovirus, using monoclonal antibodies.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2021.08.129
Abstract: Porcine astrovirus (PAstV) is prevalent in pigs worldwide and could cause clinical symptoms such as diarrhea and encephalitis. The capsid protein (Cap) of PAstV plays a determinant role for virus immunological characteristics. In this study,… read more here.
Keywords: cell epitopes; monoclonal antibodies; novel cell; capsid protein ... See more keywords
Kinetics of the association of dengue virus capsid protein with the granular component of nucleolus.
Sign Up to like & getrecommendations! Published in 2017 at "Virology"
DOI: 10.1016/j.virol.2016.12.013
Abstract: Dengue virus (DENV) replicates in the cytoplasm but translocation of the capsid protein (C) to the nucleoli of infected cells has been shown to facilitate virus multiplication for DENV-2. This study demonstrates that the nucleolar… read more here.
Keywords: dengue virus; component nucleolus; denv; capsid protein ... See more keywords
Structure-function insights into chikungunya virus capsid protein: Small molecules targeting capsid hydrophobic pocket.
Sign Up to like & getrecommendations! Published in 2018 at "Virology"
DOI: 10.1016/j.virol.2017.12.020
Abstract: The crystal structure of chikungunya (CHIKV) virus capsid protease domain has been determined at 2.2Å. Structure reveals a chymotrypsin-like protease fold with a conserved hydrophobic pocket in CHIKV capsid protein (CP) for interaction with the… read more here.
Keywords: capsid protein; hydrophobic pocket; structure; capsid ... See more keywords
The flavivirus capsid protein: Structure, function and perspectives towards drug design.
Sign Up to like & getrecommendations! Published in 2017 at "Virus research"
DOI: 10.1016/j.virusres.2016.10.005
Abstract: Flaviviruses, such as dengue and zika viruses, are etiologic agents transmitted to humans mainly by arthropods and are of great epidemiological interest. The flavivirus capsid protein is a structural element required for the viral nucleocapsid… read more here.
Keywords: drug; flavivirus; capsid protein; flavivirus capsid ... See more keywords
Transient RNA Interactions Leave a Covalent Imprint on a Viral Capsid Protein
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c12439
Abstract: The hepatitis B virus (HBV) is the leading cause of persistent liver infections. Its DNA-based genome is synthesized through reverse transcription of an RNA template inside the assembled capsid shell. In addition to the structured… read more here.
Keywords: capsid protein; rna; terminal extension; capsid ... See more keywords
Deep diversification of an AAV capsid protein by machine learning.
Sign Up to like & getrecommendations! Published in 2021 at "Nature biotechnology"
DOI: 10.1038/s41587-020-00793-4
Abstract: Modern experimental technologies can assay large numbers of biological sequences, but engineered protein libraries rarely exceed the sequence diversity of natural protein families. Machine learning (ML) models trained directly on experimental data without biophysical modeling… read more here.
Keywords: protein; aav; machine learning; capsid protein ... See more keywords
Anti-virus reagents targeting the capsid protein assembly
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Materials Chemistry B"
DOI: 10.1039/c8tb02954g
Abstract: The capsid protein is a promising target for the development of therapeutic anti-virus agents. read more here.
Keywords: capsid protein; virus reagents; reagents targeting; anti virus ... See more keywords
A hybrid HPV capsid protein L1 with giant Mo-containing polyoxometalate improves the stability of virus-like particles and the anti-tumor effect of [Mo154].
Sign Up to like & getrecommendations! Published in 2021 at "Biomaterials science"
DOI: 10.1039/d1bm00138h
Abstract: We report a bio-inorganic hybrid system, [Mo154]@VLPs, constructed from the virus-like particles (VLPs) of the HPV capsid protein L1 and a giant disc-shaped, molybdenum-containing polyoxometalate of [Mo154]. The hybrid was purified by CsCl gradient centrifugation… read more here.
Keywords: mo154; hpv capsid; virus like; capsid protein ... See more keywords