Procatechualdehyde improves mitochondrial energy metabolism through the HIF1α/PDK1 signaling pathway to mitigate ischemic stroke-elicited internal capsule injury.
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DOI: 10.1016/j.jep.2021.114232
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE The internal capsule is vulnerable to ischemia, and mild ischemic stroke often results in lesion of the internal capsule, manifested as contralateral hemiplegia. Protocatechudehyde (PCA), a potential neuroprotective agent, has shown therapeutic effects… read more here.
Keywords: ischemic stroke; capsule; capsule injury; mitochondrial energy ... See more keywords