Magnetic molecularly imprinted polymer based on dynamically established metal-mediated binding sites for the determination of trace captopril in rat plasma.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of separation science"
DOI: 10.1002/jssc.202300092
Abstract: Therapeutic drug monitoring of captopril, which is a commonly used antihypertensive agents in clinical practice, is necessary. However, matrix effect induced pretreatment is the bottleneck for determination. Metal-mediated molecularly imprinted polymers, an essential branch of… read more here.
Keywords: molecularly imprinted; captopril; metal mediated; imprinted polymer ... See more keywords
Chemoenzymatic Synthesis in Flow Reactors: A Rapid and Convenient Preparation of Captopril
Sign Up to like & getrecommendations! Published in 2017 at "ChemistryOpen"
DOI: 10.1002/open.201700082
Abstract: Abstract The chemoenzymatic flow synthesis of enantiomerically pure captopril, a widely used antihypertensive drug, is accomplished starting from simple, inexpensive, and readily available reagents. The first step is a heterogeneous biocatalyzed regio‐ and stereoselective oxidation… read more here.
Keywords: synthesis flow; chemoenzymatic synthesis; flow reactors; captopril ... See more keywords
Inhibition of Renin-Angiotensin System from Conception to Young Mature Life Induces Salt-Sensitive Hypertension via Angiotensin II-Induced Sympathetic Overactivity in Adult Male Rats.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-8023-5_5
Abstract: Previous studies indicate that perinatal compromise of taurine causes cardiovascular disorders in adults via the influence of taurine on renin-angiotensin system (RAS). This study tested whether perinatal inhibition of the RAS would itself alter the… read more here.
Keywords: adult; system; water; angiotensin ... See more keywords
Captopril attenuates oxidative stress and neuroinflammation implicated in cisplatin-induced cognitive deficits in rats
Sign Up to like & getrecommendations! Published in 2025 at "Psychopharmacology"
DOI: 10.1007/s00213-024-06706-6
Abstract: One of the most debilitating drawbacks of cisplatin chemotherapy is neurotoxicity which elicits memory impairment and cognitive dysfunction (chemobrain). This is primarily triggered by oxidative stress and inflammation. Captopril, an angiotensin-converting enzyme inhibitor, has been… read more here.
Keywords: stress; oxidative stress; stress neuroinflammation; captopril ... See more keywords
Captopril exhibits protective effects through anti-inflammatory and anti-apoptotic pathways against hydrogen peroxide-induced oxidative stress in C6 glioma cells.
Sign Up to like & getrecommendations! Published in 2022 at "Metabolic brain disease"
DOI: 10.1007/s11011-022-00948-z
Abstract: Recent studies have shown that angiotensin-converting enzyme (ACE) inhibitors have reduced oxidative damage in the central nervous system (CNS). Accumulating evidence have also demonstrated that captopril, an ACE inhibitor, has protective effects on the CNS.… read more here.
Keywords: h2o2; induced oxidative; captopril; oxidative stress ... See more keywords
The angiotensin converting enzyme (ACE) inhibitor, captopril disrupts the motility activation of sperm from the silkworm, Bombyx mori.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of insect physiology"
DOI: 10.1016/j.jinsphys.2017.09.007
Abstract: Angiotensin I-converting enzyme (also known as peptidyl dicarboxypeptidase A, ACE, and EC 3.4.15.1), which is found in a wide range of organisms, cleaves C-terminal dipeptides from relatively short oligopeptides. Mammalian ACE plays an important role… read more here.
Keywords: bombyx mori; converting enzyme; angiotensin converting; motility ... See more keywords
Investigation of the Captopril–Insulin Interaction by Mass Spectrometry and Computational Approaches Reveals that Captopril Induces Structural Changes in Insulin
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c00660
Abstract: Post-translational modifications remarkably regulate proteins’ biological function. Small molecules such as reactive thiols, metabolites, and drugs may covalently modify the proteins and cause structural changes. This study reports the covalent modification and noncovalent interaction of… read more here.
Keywords: mass spectrometric; captopril; changes insulin; structural changes ... See more keywords
The angiotensin-converting enzyme inhibitor, captopril, suppressed Hepatic Stellate Cell activation via NF-kappaB or wnt3α/β-catenin pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Bioengineered"
DOI: 10.1080/21655979.2021.1987091
Abstract: Activation of hepatic stellate cells (HSC) is associated with hepatic fibrogenesis, which is one of complications of diabetes mellitus. Captopril possesses potent anti-inflammation, oxidative stress and fibrosis effects. However, the specific molecular mechanism of captopril… read more here.
Keywords: wnt3 catenin; kappab wnt3; captopril; cell ... See more keywords
A3938 Renal angiotensin generation depends on hepatic angiotensinogen (AGT): evidence from a preclinical study with liver-targeted AGT small interfering RNA (siRNA)
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Hypertension"
DOI: 10.1097/01.hjh.0000548083.79380.91
Abstract: Objectives: AGT synthesis is believed to occur in liver, kidney, brain and adipocytes, so that selectively deleting hepatic AGT may not alter renal angiotensin (Ang) levels. Here we investigated whether arterial pressure lowering with liver-targeted… read more here.
Keywords: liver targeted; valsartan; targeted agt; agt ... See more keywords
Who Dunnit? Angiotensin, Inflammation, or Complement: Unresolved
Sign Up to like & getrecommendations! Published in 2023 at "Epilepsy Currents"
DOI: 10.1177/15357597221150057
Abstract: Captopril Alleviates Epilepsy and Cognitive Impairment by Attenuation of C3-Mediated Inflammation and Synaptic Phagocytosis Dong X, Fan J, Lin D, Wang X, Kuang H, Gong L, Chen C, Jiang J, Xia N, He D, Shen… read more here.
Keywords: inflammation; epilepsy induced; complement; captopril ... See more keywords
ACE inhibitor, captopril, attenuates cytopathic effects of herpes simplex virus 1 in SH-SY5Y cells
Sign Up to like & getrecommendations! Published in 2020 at "F1000Research"
DOI: 10.12688/f1000research.22700.1
Abstract: Background: Over 60% of the United States population is infected with herpes simplex virus 1 (HSV-1). Current HSV-1 treatment regimens exert their antiviral effects through a common mechanism of action and suffer from high dosing… read more here.
Keywords: ace inhibitor; hsv; captopril; herpes simplex ... See more keywords