Double Capture of Difluorocarbene by 2-Aminostyrenes Enables the Construction of 3-(2,2-Difluoroethyl)-2-fluoroindoles.
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DOI: 10.1021/acs.orglett.1c02816
Abstract: We report herein an efficient strategy to construct 3-(2,2-difluoroethyl)-2-fluoroindoles from activated o-aminostyrenes with ethyl bromodi-fluoroacetate as a difluorocarbene source. Through double capture of a difluorocarbene, two different types of fluorine motifs are incorporated into the… read more here.
Keywords: double capture; difluoroethyl fluoroindoles; difluorocarbene; capture difluorocarbene ... See more keywords