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Published in 2019 at "Journal of The American Society for Mass Spectrometry"
DOI: 10.1007/s13361-019-02150-5
Abstract: AbstractThere is a need in the field of biological mass spectrometry for structural tools which can report on regional, rather than solely global, structure of gaseous protein ions. Site-specific hydrogen-deuterium (H/D) exchange has shown promise…
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Keywords:
capture dissociation;
electron capture;
exchange electron;
melittin ... See more keywords
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Published in 2017 at "Analytical Chemistry"
DOI: 10.1021/acs.analchem.7b01581
Abstract: Native electron capture dissociation (NECD) is a process during which proteins undergo fragmentation similar to that from radical dissociation methods, but without the addition of exogenous electrons. However, after three initial reports of NECD from…
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Keywords:
capture dissociation;
electron capture;
dissociation;
iron binding ... See more keywords
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Published in 2019 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.8b04808
Abstract: Isomeric amino acid residues such as valine (Val) and norvaline (Nva) are common in recombinant proteins. The mis-incorporation of Nva for leucine (Leu) causes heterogeneity and in some cases even toxicity. Previous studies have shown…
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Keywords:
capture dissociation;
hot electron;
electron capture;