Engineering Novel Targeted Boron-10-Enriched Theranostic Nanomedicine to Combat against Murine Brain Tumors via MR Imaging-Guided Boron Neutron Capture Therapy.
Sign Up to like & getrecommendations! Published in 2017 at "Advanced materials"
DOI: 10.1002/adma.201700850
Abstract: Glioblastoma multiforme (GBM) is a very common type of "incurable" malignant brain tumor. Although many treatment options are currently available, most of them eventually fail due to its recurrence. Boron neutron capture therapy (BNCT) emerges… read more here.
Keywords: capture therapy; boron neutron; neutron capture; boron ... See more keywords
Tumor Eradication by Boron Neutron Capture Therapy with 10 B-enriched Hexagonal Boron Nitride Nanoparticles Grafted with Poly(glycerol).
Sign Up to like & getrecommendations! Published in 2023 at "Advanced materials"
DOI: 10.1002/adma.202301479
Abstract: Boron neutron capture therapy (BNCT) has emerged as a treatment modality with high precision and efficacy of intractable tumors. At the core of effective tumor BNCT are 10 B carriers with facile preparation as well as… read more here.
Keywords: enriched hexagonal; neutron capture; boron; boron neutron ... See more keywords
Next generation of boron neutron capture therapy (BNCT) agents for cancer treatment.
Sign Up to like & getrecommendations! Published in 2023 at "Medicinal research reviews"
DOI: 10.1002/med.21964
Abstract: Boron neutron capture therapy (BNCT) is one of the most promising treatments among neutron capture therapies due to its long-term clinical application and unequivocally obtained success during clinical trials. Boron drug and neutron play an equivalent crucial… read more here.
Keywords: therapy bnct; neutron capture; boron; boron neutron ... See more keywords
Boron agents for neutron capture therapy
Sign Up to like & getrecommendations! Published in 2020 at "Coordination Chemistry Reviews"
DOI: 10.1016/j.ccr.2019.213139
Abstract: Abstract Boron neutron capture therapy (BNCT) is a potential cancer radiotherapeutic modality, which takes advantage of the neutron capture response that occurs when boron (10B) is struck by low-energy thermal neutrons, triggering a nuclear fission… read more here.
Keywords: delivery agents; capture therapy; delivery; neutron capture ... See more keywords
Block copolymer‐boron cluster conjugate for effective boron neutron capture therapy of solid tumors
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2017.03.036
Abstract: &NA; Boron neutron capture therapy is a promising tumor treatment method, though its wide application has been limited due to the poor tumor selectivity and intracellular delivery of 10B‐compounds. Here, block copolymer‐boron cluster conjugate based… read more here.
Keywords: capture therapy; block copolymer; boron neutron; neutron capture ... See more keywords
Gadolinium nanoparticles as diagnostic and therapeutic agents: Their delivery systems in magnetic resonance imaging and neutron capture therapy
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2018.01.011
Abstract: Abstract Gadolinium (Gd) chelates have been widely used as contrast agent in magnetic resonance imaging (MRI). In addition to using MRI, they are interesting, as a radiosensitizer, in neutron capture therapy (NCT). However, the poor… read more here.
Keywords: capture therapy; resonance imaging; delivery; magnetic resonance ... See more keywords
Boron Neutron Capture Therapy Enhanced by Boronate Ester Polymer Micelles: Synthesis, Stability, and Tumor Inhibition Studies
Sign Up to like & getrecommendations! Published in 2024 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.4c00298
Abstract: Boron neutron capture therapy (BNCT) targets invasive, radioresistant cancers but requires a selective and high B-10 loading boron drug. This manuscript investigates boron-rich poly(ethylene glycol)-block-(poly(4-vinylphenyl boronate ester)) polymer micelles synthesized via atom transfer radical polymerization… read more here.
Keywords: ester polymer; boron neutron; neutron capture; tumor ... See more keywords
Design, Synthesis, and Biological Evaluation of Boron-Containing Macrocyclic Polyamines and Their Zinc(II) Complexes for Boron Neutron Capture Therapy
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.1c00445
Abstract: Boron neutron capture therapy (BNCT) is a binary therapeutic method for cancer treatment based on the use of a combination of a cancer-specific drug containing boron-10 (10B) and thermal neutron irradiation. For successful BNCT, 10B-containing… read more here.
Keywords: capture therapy; boron neutron; neutron capture; cancer ... See more keywords
The Development of Boron Analysis and Imaging in Boron Neutron Capture Therapy (BNCT).
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.1c00810
Abstract: Boron neutron capture therapy (BNCT) is a selective biological targeted nuclide technique for cancer therapy. It has the following attractive features: good targeting, high effectiveness, and causes slight damage to surrounding healthy tissue compared with… read more here.
Keywords: therapy bnct; neutron capture; therapy; boron ... See more keywords
Sweet Battle of the Epimers─Continued Exploration of Monosaccharide-Derived Delivery Agents for Boron Neutron Capture Therapy.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.3c00119
Abstract: Boron neutron capture therapy (BNCT) is a cancer therapy in which boron delivery agents play a crucial role. In theory, delivery agents with high tumor targeting capabilities can lead to selective eradication of tumor cells… read more here.
Keywords: neutron capture; delivery agents; boron neutron; capture therapy ... See more keywords
Development of a Theranostic Agent for Bone Metastases: Integration of Nuclear Medicine Imaging and Boron Neutron Capture Therapy (BNCT)
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.5c00572
Abstract: Boron neutron capture therapy (BNCT) is one of the promising cancer treatment methods with 10B-labeled compounds and neutron irradiation. The 10B(n,α)7Li reaction produces a 7Li nucleus and an α-particle with high linear energy transfer, which… read more here.
Keywords: boron neutron; neutron capture; bone metastases; medicine ... See more keywords