Vacuolin-1 inhibits endosomal trafficking and metastasis via CapZβ
Sign Up to like & getrecommendations! Published in 2021 at "Oncogene"
DOI: 10.1038/s41388-021-01662-3
Abstract: Metastasis is the fundamental cause of cancer mortality, but there are still very few anti-metastatic drugs available. Endosomal trafficking has been implicated in tumor metastasis, and we have previously found that small chemical vacuolin-1 (V1)… read more here.
Keywords: endosomal trafficking; trafficking metastasis; metastasis; capz ... See more keywords
Abstract 416: Sarcomere Disassembly After Unloading is Regulated by Ubiquitination and Acetylation of Capz and α-actinin
Sign Up to like & getrecommendations! Published in 2020 at "Circulation Research"
DOI: 10.1161/res.127.suppl_1.416
Abstract: Cardiac function mainly depends on the total myocyte mass in the ventricles. Assembly and disassembly of sarcomeres occurs to adjust this mass to altered mechanical demand. In the heart, hypertrophic cardiomyopathy results from myofibrillar assembly… read more here.
Keywords: disassembly unloading; omecamtiv mecarbil; acetylation; sarcomere disassembly ... See more keywords