The coxsackievirus and adenovirus receptor: virological and biological beauty
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Letters"
DOI: 10.1002/1873-3468.13794
Abstract: The coxsackievirus and adenovirus receptor (CAR) is an essential multifunctional cellular protein that is only beginning to be understood. CAR serves as a receptor for many adenoviruses, human group B coxsackieviruses, swine vesicular disease virus,… read more here.
Keywords: receptor virological; adenovirus receptor; receptor; virological biological ... See more keywords
Genetically Programmable Vesicles for Enhancing CAR‐T Therapy against Solid Tumors
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Materials"
DOI: 10.1002/adma.202211138
Abstract: Chimeric antigen receptor‐T (CAR‐T) cell therapy has shown remarkable success in eradicating hematologic malignancies; however, its efficacy in treating solid tumors has always been limited due to the presence of an immune‐suppressive tumor microenvironment (TME).… read more here.
Keywords: tumor; apd nvs; car; genetically programmable ... See more keywords
Magnetic–Acoustic Sequentially Actuated CAR T Cell Microrobots for Precision Navigation and In Situ Antitumor Immunoactivation
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Materials"
DOI: 10.1002/adma.202211509
Abstract: Despite its clinical success, chimeric antigen receptor T (CAR T)‐cell immunotherapy remains limited in solid tumors, owing to the harsh physical barriers and immunosuppressive microenvironment. Here a CAR‐T‐cell‐based live microrobot (M‐CAR T) is created by… read more here.
Keywords: cell; antitumor; car; magnetic acoustic ... See more keywords
Inhibition of Calcium Signaling Prevents Exhaustion and Enhances Anti‐Leukemia Efficacy of CAR‐T Cells via SOCE‐Calcineurin‐NFAT and Glycolysis Pathways
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202103508
Abstract: Abstract Chimeric antigen receptor (CAR) T cells are potent agents for recognizing and eliminating tumors, and have achieved remarkable success in the treatment of patients with refractory leukemia and lymphoma. However, dysfunction of T cells,… read more here.
Keywords: soce calcineurin; calcium; exhaustion; car ... See more keywords
Nanomodified Switch Induced Precise and Moderate Activation of CAR‐T Cells for Solid Tumors
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202205044
Abstract: Chimeric antigen receptor (CAR)‐T cell therapy is a transformative treatment against advanced malignancies. Unfortunately, once administrated in vivo, CAR‐T cells become out of artificial control, and fierce response to CAR‐T therapy may cause severe adverse… read more here.
Keywords: car; nanomodified switch; car cells; activation car ... See more keywords
CARs of the future
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Hematology"
DOI: 10.1002/ajh.25416
Abstract: CAR T cells have revolutionized the treatment of relapsed and refractory CD19‐positive leukemia and lymphoma. Unfortunately, the majority of patients treated will not achieve durable remissions. Reasons for these suboptimal clinical outcomes can be tied… read more here.
Keywords: car; hematology; cars future;
An introduction to chimeric antigen receptor (CAR) T‐cell immunotherapy for human cancer
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Hematology"
DOI: 10.1002/ajh.25418
Abstract: Chimeric antigen receptor (CAR) T‐cell therapy represents a major advancement in personalized cancer treatment. In this strategy, a patient's own T cells are genetically engineered to express a synthetic receptor that binds a tumor antigen.… read more here.
Keywords: car cell; antigen; receptor; cancer ... See more keywords
Loss of surface CD3 expression in allogeneic CAR T‐cells
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Hematology"
DOI: 10.1002/ajh.25775
Abstract: F IGURE 1 Allogeneic CAR T-cells in the clinical laboratory. A, B, Peripheral blood smear photomicrographs from patient 1 show CAR T cells in peripheral blood smear with ample cytoplasm and granules. C, Flow cytometry… read more here.
Keywords: surface cd3; allogeneic car; loss surface; car cells ... See more keywords
Prolonged hematologic toxicity following treatment with chimeric antigen receptor T cells in patients with hematologic malignancies
Sign Up to like & getrecommendations! Published in 2021 at "American Journal of Hematology"
DOI: 10.1002/ajh.26113
Abstract: Chimeric antigen receptor T‐cell therapy (CAR T) is a novel intervention for relapsed/refractory diffuse large B‐cell lymphoma (R/R DLBCL) and other hematologic malignancies. However, it is associated with prolonged hematologic toxicity (PHT) that is unpredictable… read more here.
Keywords: hematologic toxicity; cell therapy; prolonged hematologic; toxicity ... See more keywords
Chimeric antigen receptor T‐cells safety: A pharmacovigilance and meta‐analysis study
Sign Up to like & getrecommendations! Published in 2021 at "American Journal of Hematology"
DOI: 10.1002/ajh.26259
Abstract: Chimeric‐antigen‐receptor T cells directed against CD19 (CAR‐T) are emerging hematological therapeutics with scarce data on its overall safety profile spectrum. To determine the clinical features and incidence of adverse‐drug reactions (ADR) associated with CAR‐T. This… read more here.
Keywords: safety; adr; meta; car ... See more keywords
CAR‐T cell therapy targeting B cell maturation antigen is effective for relapsed/refractory multiple myeloma, including cases with poor performance status
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Hematology"
DOI: 10.1002/ajh.26583
Abstract: In this open‐label, single‐arm, phase I/II clinical trial, we evaluated the efficacy of anti‐B cell maturation antigen (BCMA) chimeric antigen receptor (CAR)‐T cell (HDS269B) therapy in 49 relapsed/refractory multiple myeloma (RRMM) patients, including 20 with… read more here.
Keywords: cell; therapy; car; maturation antigen ... See more keywords