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   Articles with "car" as a keyword



Insights Into Cardiovascular Risks of Chimeric Antigen Receptor T-Cell Therapy-From Peril to Promise.

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recommendations! Published in 2024 at "JAMA network open"

DOI: 10.1001/jamanetworkopen.2024.37157

Abstract: The development of autologous chimeric antigen receptor (CAR) T-cell therapy is a momentous breakthrough as the first personalized, genetically engineered living therapy. Reported initially at the bench in 1987, 1 over the span of the… read more here.

Keywords: receptor; cell therapy; antigen; car ... See more keywords
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The coxsackievirus and adenovirus receptor: virological and biological beauty

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recommendations! Published in 2020 at "FEBS Letters"

DOI: 10.1002/1873-3468.13794

Abstract: The coxsackievirus and adenovirus receptor (CAR) is an essential multifunctional cellular protein that is only beginning to be understood. CAR serves as a receptor for many adenoviruses, human group B coxsackieviruses, swine vesicular disease virus,… read more here.

Keywords: receptor virological; adenovirus receptor; receptor; virological biological ... See more keywords

Efficient and Traceless Aptamer-Based Serial Selection of Naïve and Early Memory CD8 T Cells for CAR T Cell Therapy.

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recommendations! Published in 2025 at "Advanced healthcare materials"

DOI: 10.1002/adhm.202502930

Abstract: Chimeric antigen receptor (CAR) T cell therapies have shown clinical success in cancer treatment. However, the compositions of the final products can differ substantially between patients, leading to variable treatment responses. Recent studies suggest that… read more here.

Keywords: aptamer; cd8 cells; car; cell ... See more keywords

Genetically Programmable Vesicles for Enhancing CAR‐T Therapy against Solid Tumors

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recommendations! Published in 2023 at "Advanced Materials"

DOI: 10.1002/adma.202211138

Abstract: Chimeric antigen receptor‐T (CAR‐T) cell therapy has shown remarkable success in eradicating hematologic malignancies; however, its efficacy in treating solid tumors has always been limited due to the presence of an immune‐suppressive tumor microenvironment (TME).… read more here.

Keywords: tumor; apd nvs; car; genetically programmable ... See more keywords

Magnetic–Acoustic Sequentially Actuated CAR T Cell Microrobots for Precision Navigation and In Situ Antitumor Immunoactivation

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recommendations! Published in 2023 at "Advanced Materials"

DOI: 10.1002/adma.202211509

Abstract: Despite its clinical success, chimeric antigen receptor T (CAR T)‐cell immunotherapy remains limited in solid tumors, owing to the harsh physical barriers and immunosuppressive microenvironment. Here a CAR‐T‐cell‐based live microrobot (M‐CAR T) is created by… read more here.

Keywords: cell; antitumor; car; magnetic acoustic ... See more keywords

A Strategy Involving Microporous Microneedles Integrated with CAR‐TREM2‐Macrophages for Scar Management by Regulating Fibrotic Microenvironment

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recommendations! Published in 2024 at "Advanced Materials"

DOI: 10.1002/adma.202406153

Abstract: Dipeptidyl peptidase 4 (DPP4) positive fibroblasts play a pivotal role in scar development following skin injury. Heterogeneous vascular endothelial cells (ECs) within scarred areas retain the capacity to drive tissue regeneration and repair. Simultaneously, TREM2… read more here.

Keywords: trem2 macrophages; microenvironment; scar; car trem2 ... See more keywords

Legumain In Situ Engineering Promotes Efferocytosis of CAR Macrophage to Treat Cardiac Fibrosis

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recommendations! Published in 2025 at "Advanced Materials"

DOI: 10.1002/adma.202417831

Abstract: Uncontrolled and excessive cardiac fibrosis after myocardial infarction (MI) is a primary contributor to mortality by heart failure. Chimeric antigen receptor macrophage (CAR‐MΦ) therapy shows great promise in cardiac fibrosis, however, the overwhelming apoptotic cells… read more here.

Keywords: fibrosis; macrophage; car; cardiac fibrosis ... See more keywords

Inhibition of Calcium Signaling Prevents Exhaustion and Enhances Anti‐Leukemia Efficacy of CAR‐T Cells via SOCE‐Calcineurin‐NFAT and Glycolysis Pathways

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recommendations! Published in 2022 at "Advanced Science"

DOI: 10.1002/advs.202103508

Abstract: Abstract Chimeric antigen receptor (CAR) T cells are potent agents for recognizing and eliminating tumors, and have achieved remarkable success in the treatment of patients with refractory leukemia and lymphoma. However, dysfunction of T cells,… read more here.

Keywords: soce calcineurin; calcium; exhaustion; car ... See more keywords

Nanomodified Switch Induced Precise and Moderate Activation of CAR‐T Cells for Solid Tumors

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recommendations! Published in 2023 at "Advanced Science"

DOI: 10.1002/advs.202205044

Abstract: Chimeric antigen receptor (CAR)‐T cell therapy is a transformative treatment against advanced malignancies. Unfortunately, once administrated in vivo, CAR‐T cells become out of artificial control, and fierce response to CAR‐T therapy may cause severe adverse… read more here.

Keywords: car; nanomodified switch; car cells; activation car ... See more keywords

Advancing Allogeneic NK Cell Immunotherapy through Microfluidic Gene Delivery

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recommendations! Published in 2025 at "Advanced Science"

DOI: 10.1002/advs.202412544

Abstract: Chimeric antigen receptor (CAR)‐T cell therapy has revolutionized cancer treatment, yet challenges such as manufacturing complexity, high costs, and safety concerns have spurred the development of alternatives like CAR‐natural killer (NK) cell immunotherapies. CAR‐NK cell… read more here.

Keywords: allogeneic cell; delivery; microfluidic gene; car ... See more keywords

From Multi‐Omics to Visualization and Beyond: Bridging Micro and Macro Insights in CAR‐T Cell Therapy

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recommendations! Published in 2025 at "Advanced Science"

DOI: 10.1002/advs.202501095

Abstract: Chimeric antigen receptor T (CAR‐T) cell therapies, a cornerstone of immunotherapy, have demonstrated remarkable efficacy in treating hematological malignancies and have more recently expanded into applications for solid tumors and autoimmune diseases. Emerging multidimensional profiling… read more here.

Keywords: visualization; multi omics; therapy; car cell ... See more keywords