Photothermal Therapy: Photothermal Therapy Promotes Tumor Infiltration and Antitumor Activity of CAR T Cells (Adv. Mater. 23/2019)
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DOI: 10.1002/adma.201970166
Abstract: CAR-T lymphocytes show modest therapeutic efficacy in solid tumors. Mild hyperthermia of the tumor reduces its compact structure and interstitial fluid pressure (IFP), increases blood perfusion, releases antigens, and promotes the recruitment of endogenous immune… read more here.
Keywords: car cells; therapy; photothermal therapy; antitumor activity ... See more keywords
Genetically Programmable Vesicles for Enhancing CAR‐T Therapy against Solid Tumors
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DOI: 10.1002/adma.202211138
Abstract: Chimeric antigen receptor‐T (CAR‐T) cell therapy has shown remarkable success in eradicating hematologic malignancies; however, its efficacy in treating solid tumors has always been limited due to the presence of an immune‐suppressive tumor microenvironment (TME).… read more here.
Keywords: tumor; apd nvs; car; genetically programmable ... See more keywords
Inhibition of Calcium Signaling Prevents Exhaustion and Enhances Anti‐Leukemia Efficacy of CAR‐T Cells via SOCE‐Calcineurin‐NFAT and Glycolysis Pathways
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DOI: 10.1002/advs.202103508
Abstract: Abstract Chimeric antigen receptor (CAR) T cells are potent agents for recognizing and eliminating tumors, and have achieved remarkable success in the treatment of patients with refractory leukemia and lymphoma. However, dysfunction of T cells,… read more here.
Keywords: soce calcineurin; calcium; exhaustion; car ... See more keywords
Nanomodified Switch Induced Precise and Moderate Activation of CAR‐T Cells for Solid Tumors
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DOI: 10.1002/advs.202205044
Abstract: Chimeric antigen receptor (CAR)‐T cell therapy is a transformative treatment against advanced malignancies. Unfortunately, once administrated in vivo, CAR‐T cells become out of artificial control, and fierce response to CAR‐T therapy may cause severe adverse… read more here.
Keywords: car; nanomodified switch; car cells; activation car ... See more keywords
Loss of surface CD3 expression in allogeneic CAR T‐cells
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DOI: 10.1002/ajh.25775
Abstract: F IGURE 1 Allogeneic CAR T-cells in the clinical laboratory. A, B, Peripheral blood smear photomicrographs from patient 1 show CAR T cells in peripheral blood smear with ample cytoplasm and granules. C, Flow cytometry… read more here.
Keywords: surface cd3; allogeneic car; loss surface; car cells ... See more keywords
Cancer Immunotherapy Using CAR‐T Cells: From the Research Bench to the Assembly Line
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DOI: 10.1002/biot.201700097
Abstract: The focus of cancer treatment has recently shifted toward targeted therapies, including immunotherapy, which allow better individualization of care and are hoped to increase the probability of success for patients. Specifically, T cells genetically modified… read more here.
Keywords: car cells; cell; car; cancer immunotherapy ... See more keywords
Therapeutic effects of anti-GM2 CAR-T cells expressing IL-7 and CCL19 for GM2-positive solid cancer in xenograft model.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer medicine"
DOI: 10.1002/cam4.5907
Abstract: BACKGROUND While chimeric antigen receptor (CAR)-T cell therapy has demonstrated excellent efficacy in hematopoietic malignancies, its clinical application in solid cancers has yet to be achieved. One of the reasons for such hurdle is a… read more here.
Keywords: car; anti gm2; car cells; cancer ... See more keywords
Anti‐CLL1‐based CAR T‐cells with 4‐1‐BB or CD28/CD27 stimulatory domains in treating childhood refractory/relapsed acute myeloid leukemia
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DOI: 10.1002/cam4.5916
Abstract: Though the efficacy of anti C‐type lectin‐like molecule‐1 (CLL1) CAR T‐cells in refractory/relapsed acute myeloid leukemia (R/R‐AML) have been occasionally reported, the influence of co‐stimulatory domain CAR T‐cells is not investigated so far. read more here.
Keywords: refractory relapsed; myeloid leukemia; car; acute myeloid ... See more keywords
Light‐Controllable Binary Switch Activation of CAR T Cells
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DOI: 10.1002/cmdc.202100722
Abstract: Major challenges to chimeric antigen receptor (CAR) T cell therapies include uncontrolled immune activity, off‐tumor toxicities and tumor heterogeneity. To overcome these challenges, we engineered CARs directed against small molecules. By conjugating the same small… read more here.
Keywords: cell; tumor; car; car cell ... See more keywords
CAR NK-92 cells targeting DLL3 kill effectively small cell lung cancer cells in vitro and in vivo.
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DOI: 10.1002/jlb.5ma0122-467r
Abstract: Small cell lung cancer (SCLC) is characterized by a high relapse rate, drug tolerance, and limited treatment choices. Chimeric antigen receptor (CAR)-modified NK cells represent a promising immunotherapeutic modality for cancer treatment. However, their potential… read more here.
Keywords: dll3; dll3 car; car cells; cancer ... See more keywords
Tumor‐intrinsic CD21 expression impacts the response of B‐cell malignancy cells to CD19‐CAR‐T cells
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DOI: 10.1002/jlb.5ma0122-474r
Abstract: CD19‐chimeric antigen receptor (CAR)‐based T‐cell therapy has produced promising clinical responses in patients with relapsed or refractory B‐cell malignancies. However, a significant portion of patients with mature B cell‐derived malignancies, including chronic lymphocytic leukemia (CLL)… read more here.
Keywords: cell; cd19 car; cells cd19; car ... See more keywords