The best spot to park a CAR
Sign Up to like & getrecommendations! Published in 2017 at "Nature Biotechnology"
DOI: 10.1038/nbt.3848
Abstract: 341 Cancer immunotherapy using T cells engineered to express chimeric antigen receptors (CARs) has achieved exciting results in patients with B-cell malignancies. In a recent report in Nature, Eyquem et al.1 sought to improve the… read more here.
Keywords: car cells; car expression; car; gene edited ... See more keywords
Abstract 3199: Development of a flow cytometry-based assay for measuring specific CAR expression on LGR5-targeting CAR-T cells
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3199
Abstract: The measurement of chimeric antigen receptor (CAR) expression is critical for the development, qualification and quantitation of CAR-T cells for clinical applications. There is a comprehensive range of tools commercially available for specifically measuring expression… read more here.
Keywords: car expression; targeting car; development; expression ... See more keywords
Surface Density of CAR Molecules May Modulate the Kinetics of CAR-T Cells In Vivo
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-125467
Abstract: Introduction: The various chimeric antigen receptor (CAR) genes used in most CAR-T clinical trials are expressed via the EF1α promoter. Recent reports have suggested that CAR expression using the myeloproliferative sarcoma virus enhancer, with the… read more here.
Keywords: car expression; surface; 1904a 1904b; expression ... See more keywords
The Contribution of the Minimal Promoter Element to the Activity of Synthetic Promoters Mediating CAR Expression in the Tumor Microenvironment
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23137431
Abstract: Harnessing immune effector cells to benefit cancer patients is becoming more and more prevalent in recent years. However, the increasing number of different therapeutic approaches, such as chimeric antigen receptors and armored chimeric antigen receptors,… read more here.
Keywords: promoter; car expression; chimeric antigen; expression ... See more keywords