Building better CAR-T therapies.
Sign Up to like & getrecommendations! Published in 2020 at "Nature"
DOI: 10.1038/d41586-020-02675-w
Abstract: The current technique requires a person’s own cells, but using the cells of healthy donors could allow more people to benefit. The current technique requires a person’s own cells, but using the cells of healthy… read more here.
Keywords: building better; better car; car therapies;
The key to unlocking CARs
Sign Up to like & getrecommendations! Published in 2017 at "Nature Biotechnology"
DOI: 10.1038/nbt.3993
Abstract: 889 input donor blood cells (e.g., starting cell number and exposure to different treatments and conditioning regimens). Some groups are also experimenting with a decentralized delivery model employing user-friendly, automated, closed manufacturing devices to grow… read more here.
Keywords: car therapies; treatment; therapy; cell ... See more keywords
Combating challenges in CAR-T cells with engineering immunology
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.969020
Abstract: Chimeric antigen receptors (CAR) T cells (CAR-T) mark a significant step towards producing safe and effective personal anticancer treatments. CAR-T strategies engineers the T cells from the patients to allow specific binding to a tumour-specific… read more here.
Keywords: car therapies; engineering immunology; car; car cells ... See more keywords
When Onco-Immunotherapy Meets Cold Atmospheric Plasma: Implications on CAR-T Therapies
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.837995
Abstract: T cells engineered with chimeric antigen receptors (CAR) have demonstrated its widespread efficacy as a targeted immunotherapeutic modality. Yet, concerns on its specificity, efficacy and generalization prevented it from being established into a first-line approach… read more here.
Keywords: cold atmospheric; onco immunotherapy; car therapies; atmospheric plasma ... See more keywords
Alternative CAR Therapies: Recent Approaches in Engineering Chimeric Antigen Receptor Immune Cells to Combat Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10071493
Abstract: For nearly three decades, chimeric antigen receptors (CARs) have captivated the interest of researchers seeking to find novel immunotherapies to treat cancer. CARs were first designed to work with T cells, and the first CAR… read more here.
Keywords: alternative car; car therapies; chimeric antigen; car ... See more keywords
CAR-T: What Is Next?
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15030663
Abstract: Simple Summary In 2017, two chimeric antigen receptor-T (CAR-T) therapies were approved by the FDA for advanced/resistant lymphoma and acute lymphoblastic leukemia. However, despite the breakthrough efficacy results, the safety of CAR-T treatment is still… read more here.
Keywords: car therapy; car therapies; car; efficacy ... See more keywords