Population‐based cellular kinetic characterization of ciltacabtagene autoleucel in subjects with relapsed or refractory multiple myeloma
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DOI: 10.1111/cts.13421
Abstract: The aims of this work were to develop a population pharmacokinetic (PK) model for chimeric antigen receptor (CAR) transgene after single intravenous infusion administration of ciltacabtagene autoleucel in adult patients with relapsed or refractory multiple… read more here.
Keywords: car transgene; relapsed refractory; ciltacabtagene autoleucel; car ... See more keywords
Abstract CT237: Evaluation of in vivo chimeric antigen receptor (CAR) transgene levels in patients (pts) treated with tisagenlecleucel
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DOI: 10.1158/1538-7445.am2019-ct237
Abstract: Background: Following infusion of tisagenlecleucel, quantitative polymerase chain reaction (qPCR) can be used to measure in vivo kinetics of CAR transgene. The utility of qPCR to inform individual pt treatment decisions and measure functional persistence… read more here.
Keywords: evaluation vivo; transgene levels; car transgene; transgene ... See more keywords