Activity of CAR19 T cells secreting impact fusion proteins against hematopoietic and solid tumors.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.e15046
Abstract: e15046Background: CAR T cells targeting CD19 (CAR19s) can eradicate B cell leukemias and lymphomas. We have engineered CAR19s to secrete a wide variety of retargeting fusion proteins (FP) by encodi... read more here.
Keywords: fusion proteins; activity car19; cells secreting; car19 cells ... See more keywords
PiggyBac-Generated CAR19-T Cells Plus Lenalidomide Cause Durable Complete Remission of Triple-Hit Refractory/Relapsed DLBCL: A Case Report
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.599493
Abstract: MYC/BCL2/BCL6 triple-hit lymphoma (THL) is an uncommon subset of high-grade B-cell lymphoma with aggressive clinical behavior and poor prognosis. TP53 mutation is an independently poor progonistic indicator in patients with THL, hence novel therapeutic strategies… read more here.
Keywords: triple hit; car19 cells; therapy; car19 ... See more keywords