Carba Analogues of Flupirtine and Retigabine with Improved Oxidation Resistance and Reduced Risk of Quinoid Metabolite Formation
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DOI: 10.1002/cmdc.202200262
Abstract: The KV7 potassium channel openers flupirtine and retigabine have been valuable options in the therapy of pain and epilepsy. However, as a result of adverse reactions, both drugs are currently no longer in therapeutic use.… read more here.
Keywords: improved oxidation; carba analogues; flupirtine retigabine; oxidation resistance ... See more keywords