Synthesis, molecular docking and molecular dynamics studies of novel tacrine-carbamate derivatives as potent cholinesterase inhibitors.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.105225
Abstract: In the present study, new tacrine derivatives containing carbamate group were synthesized and their acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibition activities were evaluated. All synthesized compounds inhibited both cholinesterases at nanomolar level. Among them, ((1,2,3,4-tetrahydroacridin-9-yl)amino)ethyl(3-nitrophenyl)… read more here.
Keywords: synthesized compounds; buche; carbamate derivatives; carbamate ... See more keywords
Synthesis of multifunctional 4-hydroxymethyl 2-oxazolidinones from glycidyl carbamate derivatives catalyzed by bicyclic guanidine
Sign Up to like & getrecommendations! Published in 2021 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2021.153086
Abstract: Abstract 4-Hydroxymethyl 2-oxazolidinones have been successfully synthesized under mild conditions by the intramolecular cyclization of glycidyl carbamate derivatives with a bicyclic guanidine as the efficient catalyst. This reaction system, which is also applicable to the… read more here.
Keywords: synthesis multifunctional; carbamate derivatives; glycidyl carbamate; hydroxymethyl oxazolidinones ... See more keywords
Design, synthesis and antifungal activity of threoninamide carbamate derivatives via pharmacophore model
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2020.1729144
Abstract: Abstract Thirty-six novel threoninamide carbamate derivatives were designed and synthesised using active fragment-based pharmacophore model. Antifungal activities of these compounds were tested against Oomycete fungi Phytophthora capsici in vitro and in vivo. Interestingly, compound I-1,… read more here.
Keywords: design synthesis; synthesis antifungal; carbamate derivatives; pharmacophore model ... See more keywords
Synthesis of Some Unique Carbamate Derivatives bearing 2-Furoyl-1-piperazine as a Valuable Therapeutic Agents.
Sign Up to like & getrecommendations! Published in 2017 at "Acta chimica Slovenica"
DOI: 10.17344/acsi.2016.2986
Abstract: The aim of the research work was to synthesize different biologically active carbamate derivatives bearing 2-furoyl-1-piperazine and having modest toxicity. The synthesis was completed as a multiple sequence. The structural confirmation of all the synthesized… read more here.
Keywords: derivatives bearing; bearing furoyl; carbamate derivatives; furoyl piperazine ... See more keywords
In Vitro versus in Mice: Efficacy and Safety of Decoquinate and Quinoline-O-Carbamate Derivatives against Experimental Infection with Neospora caninum Tachyzoites
Sign Up to like & getrecommendations! Published in 2023 at "Pathogens"
DOI: 10.3390/pathogens12030447
Abstract: The effects of decoquinate (DCQ) and three O-quinoline-carbamate-derivatives were investigated using human foreskin fibroblasts (HFF) infected with Neospora caninum tachyzoites. These compounds exhibited half-maximal proliferation inhibition (IC50s) from 1.7 (RMB060) to 60 nM (RMB055). Conversely,… read more here.
Keywords: caninum tachyzoites; neospora caninum; carbamate derivatives; efficacy safety ... See more keywords
Antibacterial properties and carbonic anhydrase inhibition profiles of azido sulfonyl carbamate derivatives.
Sign Up to like & getrecommendations! Published in 2021 at "Future medicinal chemistry"
DOI: 10.4155/fmc-2020-0387
Abstract: Aim: The aim of this study was to identify inhibition of carbonic anhydrase I and II (CA I and II) isozymes by azido sulfonyl carbamates through both in vitro and in silico approaches and also… read more here.
Keywords: azido sulfonyl; carbonic anhydrase; sulfonyl carbamate; inhibition ... See more keywords