Design, synthesis, and evaluation of potential carbamate prodrugs of 5′-methylthioadenosine (MTA)
Sign Up to like & getrecommendations! Published in 2021 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-021-02730-9
Abstract: 5′-Methylthioadenosine (MTA) is a natural substrate of MTA phosphorylase (MTAP) and is converted to adenine via a salvage pathway for AMP production in normal healthy cells. The lack of MTAP expression in many solid tumors… read more here.
Keywords: carbamate prodrugs; normal healthy; methylthioadenosine mta; design synthesis ... See more keywords