Discovery of Novel 2-Carbamoyl Morpholine Derivatives as Highly Potent and Orally Active Direct Renin Inhibitors.
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DOI: 10.1021/acsmedchemlett.2c00280
Abstract: The renin-angiotensin-aldosterone system (RAAS) plays a key role in the regulation of blood pressure. Renin, the first and rate-limiting enzyme of the RAAS, is an attractive target for the treatment of hypertension and cardiovascular/renal diseases.… read more here.
Keywords: carbamoyl morpholine; highly potent; direct renin; renin inhibitors ... See more keywords