Site-Specific Detection and Characterization of Ubiquitin Carbamylation.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00085
Abstract: The physiological consequences of varying in vivo CO2 levels point to a general mechanism for CO2 to influence cellular homeostasis beyond regulating pH. Aside from a few instances where CO2 has been observed to cause… read more here.
Keywords: characterization ubiquitin; ubiquitin carbamylation; carbamylation; specific detection ... See more keywords
Carbamylation Promotes Sequence-Specific Amyloidogenesis in the α-Synuclein KTKEGV Repeat Motifs.
Sign Up to like & getrecommendations! Published in 2025 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.5c00561
Abstract: KTKEGV repeat motifs play a crucial role in regulating the folding of α-synuclein structure and function, including tetramer formation and interaction with membranes. In α-syn, nine KTKEGV imperfect repeats have been reported. Post-translational modifications (PTMs)… read more here.
Keywords: ktkegv repeat; repeat motifs; carbamylation; aggregation ... See more keywords
Neutrophil extracellular trap-associated carbamylation and histones trigger osteoclast formation in rheumatoid arthritis
Sign Up to like & getrecommendations! Published in 2023 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/ard-2022-223568
Abstract: Objective Neutrophil infiltration into the synovial joint is a hallmark of rheumatoid arthritis (RA), a disease characterised by progressive bone erosion. However, the mechanisms by which neutrophils participate in bone destruction remain unclear. Carbamylation is… read more here.
Keywords: bone; carbamylation; rheumatoid arthritis; neutrophil extracellular ... See more keywords
Comparative CKD risk prediction using homocitrulline and carbamylated albumin: two circulating markers of protein carbamylation
Sign Up to like & getrecommendations! Published in 2024 at "BMC Nephrology"
DOI: 10.1186/s12882-024-03619-6
Abstract: Protein carbamylation, a post-translational protein modification primarily driven by urea, independently associates with adverse clinical outcomes in patients with CKD. Biomarkers used to quantify carbamylation burden have mainly included carbamylated albumin (C-Alb) and homocitrulline (HCit,… read more here.
Keywords: alb hcit; carbamylated albumin; protein carbamylation; carbamylation ... See more keywords
The Impact of Carbamylation and Anemia on HbA1c’s Association With Renal Outcomes in Patients With Diabetes and Chronic Kidney Disease
Sign Up to like & getrecommendations! Published in 2022 at "Diabetes Care"
DOI: 10.2337/dc22-1399
Abstract: OBJECTIVE Glycated hemoglobin (HbA1c) can predict risk for microvascular complications in patients with diabetes. However, HbA1c’s reliability in chronic kidney disease (CKD) has been questioned, with concerns including competition from another posttranslational protein modification, carbamylation,… read more here.
Keywords: hba1c; carbamylation; anemia; ckd progression ... See more keywords
Carbamylated Proteins in Renal Disease: Aggravating Factors or Just Biomarkers?
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23010574
Abstract: Carbamylation is a nonenzymatic post-translational modification resulting from the reaction between cyanate, a urea by-product, and proteins. In vivo and in vitro studies have demonstrated that carbamylation modifies protein structures and functions, triggering unfavourable molecular… read more here.
Keywords: aggravating factors; carbamylated proteins; renal disease; carbamylation ... See more keywords