A Novel Algorithm to Analyze Epidemiology and Outcomes of Carbapenem Resistance Among Patients With Hospital-Acquired and Ventilator-Associated Pneumonia: A Retrospective Cohort Study.
Sign Up to like & getrecommendations! Published in 2019 at "Chest"
DOI: 10.1016/j.chest.2018.12.024
Abstract: BACKGROUND Carbapenem resistance is a growing concern. Applying a novel algorithm, we examined epidemiology and outcomes of carbapenem resistance among gram-negative pathogens in hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP). METHODS In a retrospective cohort… read more here.
Keywords: novel algorithm; epidemiology; carbapenem resistance;
Molecular insights of Carbapenem resistance Klebsiella pneumoniae isolates with focus on multidrug resistance from clinical samples.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of infection and public health"
DOI: 10.1016/j.jiph.2020.09.018
Abstract: BACKGROUND Carbapenem are the last-line antibiotic, defence against Gram-negative extended spectrum ß-lactamases producers (ESBLs). Carbapenem resistance Enterobacteriaceae especially Carbapenem resistant-Klebsiella pneumoniae (CR-KP) is recognized as one of the well-known public health problem, which is increasingly… read more here.
Keywords: pneumoniae; carbapenem resistance; resistance; klebsiella pneumoniae ... See more keywords
Rapid detection of carbapenem resistance among gram-negative organisms directly from positive blood culture bottles
Sign Up to like & getrecommendations! Published in 2021 at "Medical Journal Armed Forces India"
DOI: 10.1016/j.mjafi.2021.03.026
Abstract: Abstract Background Carbapenemase producing gram-negative bacteria (GNB) has become a huge problem in majority of tertiary care centers worldwide. They are associated with very high morbidity and mortality rates, especially when they cause invasive infections.… read more here.
Keywords: gram negative; rapid detection; resistance; carbapenem resistance ... See more keywords
OmpK36-mediated Carbapenem resistance attenuates ST258 Klebsiella pneumoniae in vivo
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-11756-y
Abstract: Carbapenem-resistance in Klebsiella pneumoniae (KP) sequence type ST258 is mediated by carbapenemases (e.g. KPC-2) and loss or modification of the major non-selective porins OmpK35 and OmpK36. However, the mechanism underpinning OmpK36-mediated resistance and consequences of… read more here.
Keywords: klebsiella pneumoniae; resistance; carbapenem resistance; ompk36 mediated ... See more keywords
Prevalence and Mechanisms of Carbapenem Resistance Among Acinetobacter baumannii Clinical Isolates in Egypt.
Sign Up to like & getrecommendations! Published in 2019 at "Microbial drug resistance"
DOI: 10.1089/mdr.2018.0141
Abstract: The increasing number of carbapenem-resistant Acinetobacter baumannii clinical isolates is a major concern, which restricts therapeutic options for treatment of serious infections caused by this emerging pathogen. The aim of this work is to assess… read more here.
Keywords: carbapenem resistance; resistance; clinical isolates; baumannii clinical ... See more keywords
Increased Plasmid Copy Number Contributes to the Elevated Carbapenem Resistance in OXA-232-Producing Klebsiella pneumoniae.
Sign Up to like & getrecommendations! Published in 2019 at "Microbial drug resistance"
DOI: 10.1089/mdr.2018.0407
Abstract: A total of 345 unique (one isolate per patient) clinical carbapenem-resistant Klebsiella pneumoniae isolates were recovered in our hospital over the past 3 years (2016-2018), with 325, 14, and 6 isolates carried blaKPC-2, blaNDM-1, and… read more here.
Keywords: oxa 232; elevated carbapenem; carbapenem resistance; blaoxa 232 ... See more keywords
High Carbapenem Resistance Caused by VIM and NDM Enzymes and OprD Alteration in Nonfermenter Bacteria Isolated from a Libyan Hospital.
Sign Up to like & getrecommendations! Published in 2021 at "Microbial drug resistance"
DOI: 10.1089/mdr.2020.0175
Abstract: Acinetobacter baumannii and Pseudomonas aeruginosa are among the most prevalent pathogens causing a wide range of serious infections in hospitalized patients and contaminating intensive care units and inanimate surfaces. The purpose of this study was… read more here.
Keywords: isolates baumannii; libyan hospital; carbapenem resistance; resistance ... See more keywords
Development of carbapenem resistance in Pseudomonas aeruginosa is associated with OprD polymorphisms, particularly the amino acid substitution at codon 170
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkx158
Abstract: Objectives: Pan‐susceptible Pseudomonas aeruginosa (PSPA) clinical isolates carrying an OprD with loop 7 shortening (the group‐1A allele) were found to rapidly develop carbapenem resistance under continuous selection pressure. We further studied whether OprD polymorphisms are… read more here.
Keywords: pseudomonas aeruginosa; carbapenem resistance; oprd polymorphisms; resistance ... See more keywords
Evolution of carbapenem resistance in Acinetobacter baumannii during a prolonged infection
Sign Up to like & getrecommendations! Published in 2018 at "Microbial Genomics"
DOI: 10.1099/mgen.0.000165
Abstract: Acinetobacter baumannii is a common causative agent of hospital-acquired infections and a leading cause of infection in burns patients. Carbapenem-resistant A. baumannii is considered a major public-health threat and has been identified by the World… read more here.
Keywords: carbapenem resistance; evolution carbapenem; resistance; acinetobacter baumannii ... See more keywords
The impact of carbapenem resistance on clinical deterioration and mortality in patients with liver disease
Sign Up to like & getrecommendations! Published in 2017 at "Liver International"
DOI: 10.1111/liv.13438
Abstract: Infections with multidrug‐resistant gram‐negative bacteria are significantly impairing the prognosis of patients with liver disease. In particular, carbapenem resistance further narrows therapeutic options. This study investigates the impact of carbapenem‐resistant gram‐negative bacteria on the outcome… read more here.
Keywords: liver disease; impact carbapenem; patients liver; carbapenem resistance ... See more keywords
4-Amino-2-Sulfanylbenzoic Acid as a Potent Subclass B3 Metallo-β-Lactamase-Specific Inhibitor Applicable for Distinguishing Metallo-β-Lactamase Subclasses
Sign Up to like & getrecommendations! Published in 2019 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.01197-19
Abstract: The number of cases of infection with carbapenem-resistant Enterobacteriaceae (CRE) has been increasing and has become a major clinical and public health concern. Production of metallo-β-lactamases (MBLs) is one of the principal carbapenem resistance mechanisms… read more here.
Keywords: lactamase; metallo lactamase; mbl inhibitors; smb ... See more keywords