Design and synthesis of N–acetylglucosamine derived 5a-carbasugar analogues as glycosidase inhibitors
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DOI: 10.1016/j.tet.2018.02.063
Abstract: Abstract An efficient synthesis of new six-membered carbasugars in both L-form and D-form starting from N–acetylglucosamine is described. The key synthetic steps involved regioselective protection and deprotection, Ferrier carbocyclization, Peterson olefination, hydroboration and stereoselective epoxidation… read more here.
Keywords: design synthesis; synthesis acetylglucosamine; synthesis; derived carbasugar ... See more keywords
Stereoselective Synthesis and Evaluation of C6″-Substituted 5a-Carbasugar Analogues of SL0101 as Inhibitors of RSK1/2.
Sign Up to like & getrecommendations! Published in 2017 at "Organic letters"
DOI: 10.1021/acs.orglett.7b00945
Abstract: A convergent synthesis of 5a-carbasugar analogues of the n-Pr-variant of SL0101 is described. The analogues were synthesized in an effort to find compounds with potent in vivo efficacy in the inhibition of p90 ribosomal s6… read more here.
Keywords: stereoselective synthesis; carbasugar analogues; synthesis evaluation; evaluation substituted ... See more keywords