Nickel-Catalyzed Formation of α-Substituted γ-Amino Ketones via Alkene Carboacylation.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c03413
Abstract: Herein, we report Ni-catalyzed intramolecular carboacylation of imides containing a tethered alkene and tetraarylborate nucleophiles. Using a nickel-phosphine catalyst system, α-substituted, γ-amino ketones are generated in up to 92% yield with site selectivity. Deprotection and… read more here.
Keywords: catalyzed formation; nickel catalyzed; amino ketones; substituted amino ... See more keywords
Ni-Catalyzed Alkene Carboacylation via Amide C-N Bond Activation.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b06191
Abstract: We report Ni-catalyzed formal carboacylation of o-allylbenzamides with arylboronic acid pinacol esters. The reaction is triggered by oxidative addition of an activated amide C-N bond to a Ni(0) catalyst and proceeds via alkene insertion into… read more here.
Keywords: alkene carboacylation; carboacylation; bond; bond activation ... See more keywords