A Counterion/Ligand-Tuned Chemo- and Enantioselective Copper-Catalyzed Intermolecular Radical 1,2-Carboamination of Alkenes.
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DOI: 10.1021/jacs.2c08035
Abstract: The copper-catalyzed enantioselective intermolecular radical 1,2-carboamination of alkenes with readily accessible alkyl halides is an appealing strategy for producing chiral amine scaffolds. The challenge arises from the easily occurring atom transfer radical addition between alkyl… read more here.
Keywords: copper; radical carboamination; ligand; copper catalyzed ... See more keywords
Intermolecular Carboamination of Unactivated Alkenes.
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DOI: 10.1021/jacs.8b07023
Abstract: Herein, we report the first example of group transfer radical addition of O-vinylhydroxylamine derivatives onto unactivated alkenes. By utilizing O-vinylhydroxylamine derivatives as both the N- and C-donors, this reaction enables intermolecular carboamination of unactivated alkenes… read more here.
Keywords: carboamination; carboamination unactivated; intermolecular carboamination; unactivated alkenes ... See more keywords
1,2-Difunctionalizations of alkynes entailing concomitant C–C and C–N bond-forming carboamination reactions
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DOI: 10.1039/d1ra06633a
Abstract: Vicinal carboamination of alkynes is a highly reliable and efficient practical strategy for the quick preparation of valuable and diverse amine derivatives starting from simple synthons. The last decade has witnessed numerous practical methods employing… read more here.
Keywords: concomitant bond; difunctionalizations alkynes; alkynes entailing; metal ... See more keywords
Visible-light promoted intramolecular carboamination of alkynes for the synthesis of oxazolidinone-fused isoquinolinones.
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DOI: 10.1039/d2cc06542h
Abstract: An efficient method for the synthesis of isoquinolinone derivatives via photopromoted carboamination of alkynes is developed. Starting from the readily available propargyl alcohol derivatives, the polycyclic isoquinolinone derivatives could be obtained with good aryl and… read more here.
Keywords: light promoted; intramolecular carboamination; promoted intramolecular; visible light ... See more keywords