Selective Vinylogous Reactivity of Carbene Intermediate in Gold-Catalyzed Alkyne Carbocyclization: Synthesis of Indenols
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DOI: 10.1021/acscatal.8b04144
Abstract: A gold-catalyzed carbocyclization of alkynes with a pendant diazo group that is completed by reaction with a protic nucleophile for the synthesis of indenol derivatives with a tertiary center is described. Mechanistic studies and DFT… read more here.
Keywords: selective vinylogous; synthesis; gold catalyzed; carbocyclization ... See more keywords
Synthesis of heteroatom-containing pyrrolidine derivatives based on Ti(O-iPr)4 and EtMgBr-catalyzed carbocyclization of allylpropargyl amines with Et2Zn
Sign Up to like & getrecommendations! Published in 2020 at "RSC Advances"
DOI: 10.1039/d0ra02677h
Abstract: The Ti(O-iPr)4 and EtMgBr-catalyzed regio and stereoselective carbocyclization of N-allyl-substituted 2-alkynylamines with Et2Zn, followed by deuterolysis or hydrolysis, affords the corresponding methylenepyrrolidine derivatives in high yields. It was found that Ti–Mg-catalyzed carbocyclization of N-allyl-substituted 2-alkynylamines… read more here.
Keywords: allylpropargyl amines; ipr etmgbr; pyrrolidine derivatives; catalyzed carbocyclization ... See more keywords
Alkynyl Prins carbocyclization cascades for the synthesis of linear-fused heterocyclic ring systems
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DOI: 10.1039/d2sc04750k
Abstract: We report a Brønsted acid-catalyzed carbocyclization cascade, featuring condensation of an alcohol/sulfonamide with an aldehyde followed by an intramolecular three-component coupling involving an alkyne, an oxocarbenium/iminium ion, and an arene. A formal cycloaddition is embedded… read more here.
Keywords: carbocyclization cascades; cascades synthesis; chemistry; prins carbocyclization ... See more keywords