The unique evolution of the carbohydrate‐binding module CBM20 in laforin
Sign Up to like & getrecommendations! Published in 2018 at "FEBS Letters"
DOI: 10.1002/1873-3468.12994
Abstract: Laforin catalyses glycogen dephosphorylation. Mutations in its gene result in Lafora disease, a fatal progressive myoclonus epilepsy, the hallmark being water‐insoluble, hyperphosphorylated carbohydrate inclusions called Lafora bodies. Human laforin consists of an N‐terminal carbohydrate‐binding module… read more here.
Keywords: cbm20 laforin; carbohydrate binding; binding module; laforin ... See more keywords
FAM3B/PANDER-Like Carbohydrate-Binding Domain in a Glycosyltransferase, POMGNT1.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0430-4_52
Abstract: Protein O-mannose β1,2-N-acetylglucosaminyltransferase 1 (POMGNT1) is one of the gene products responsible for α-dystroglycanopathy, which is a type of congenital muscular dystrophy caused by O-mannosyl glycan defects. The originally identified function of POMGNT1 was as… read more here.
Keywords: pomgnt1; carbohydrate binding; domain; glycosyltransferase ... See more keywords
Absence of the highly expressed small carbohydrate-binding protein Cgt improves the acarbose formation in Actinoplanes sp. SE50/110
Sign Up to like & getrecommendations! Published in 2020 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-020-10584-1
Abstract: Actinoplanes sp. SE50/110 (ATCC 31044) is the wild type of industrial producer strains of acarbose. Acarbose has been used since the early 1990s as an inhibitor of intestinal human α-glucosidases in the medical treatment of… read more here.
Keywords: actinoplanes se50; carbohydrate binding; cgt; protein cgt ... See more keywords
Fusion of carbohydrate binding module to mutant alkaline phosphatase for immobilization on cellulose
Sign Up to like & getrecommendations! Published in 2018 at "Biocatalysis and agricultural biotechnology"
DOI: 10.1016/j.bcab.2018.01.003
Abstract: Abstract Immobilized alkaline phosphatase (AP) has the potential to be utilized in biotechnology applications including molecular cloning, inhibitor screening, and the production of phosphorylated compounds. Traditional immobilization methods are limited by specificity and reproducibility, and… read more here.
Keywords: phosphatase; immobilization; carbohydrate binding; mutant alkaline ... See more keywords
Transcriptional control of brain tumor stem cells by a carbohydrate binding protein.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109647
Abstract: Brain tumor stem cells (BTSCs) and intratumoral heterogeneity represent major challenges in glioblastoma therapy. Here, we report that the LGALS1 gene, encoding the carbohydrate binding protein, galectin1, is a key regulator of BTSCs and glioblastoma… read more here.
Keywords: carbohydrate binding; tumor stem; binding protein; brain tumor ... See more keywords
Effect of carbohydrate binding modules alterations on catalytic activity of glycoside hydrolase family 6 exoglucanase form Chaetomium thermophilum to cellulose.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2021.09.002
Abstract: Exoglucanase (CBH) is the rate limiting enzyme in the process of cellulose degradation. The carbohydrate binding module (CBM) can improve the accessibility of cellulase to substrate, thereby promoting the enzymatic hydrolysis of cellulase. In this… read more here.
Keywords: cbm; chaetomium thermophilum; carbohydrate binding; catalytic activity ... See more keywords
Structure and Ligand-Binding Properties of the O Antigen ABC Transporter Carbohydrate-Binding Domain.
Sign Up to like & getrecommendations! Published in 2019 at "Structure"
DOI: 10.1016/j.str.2019.11.020
Abstract: A hallmark of Gram-negative bacteria is an asymmetric outer membrane containing lipopolysaccharides (LPSs) in the extracellular leaflet. LPS molecules consist of lipid A, which is connected to the inner and outer core oligosaccharides. This LPS… read more here.
Keywords: abc transporter; binding domain; carbohydrate binding; structure ... See more keywords
Biological route to fabricate silica on cellulose using immobilized silicatein fused with a carbohydrate-binding module.
Sign Up to like & getrecommendations! Published in 2020 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.0c00730
Abstract: Silicatein is an enzyme capable of catalyzing silica formation under mild conditions and is a promising catalyst for the fabrication of biohybrid materials. However, unfavorable aggregation of silicatein makes it unsuitable for use in material… read more here.
Keywords: silica cellulose; silica; carbohydrate binding; binding module ... See more keywords
Dual α-1,4- and β-1,4-Glycosidase Activities by the Novel Carbohydrate-Binding Module in α-l-Fucosidase from Vibrio sp. Strain EJY3.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.0c08199
Abstract: Carbohydrates are structurally and functionally diverse materials including polysaccharides, and marine organisms are known to have many enzymes for the breakdown of complex polysaccharides. Here, we identified an α-l-fucosidase enzyme from the marine bacterium Vibrio… read more here.
Keywords: glycosidase activities; carbohydrate binding; dual glycosidase; strain ejy3 ... See more keywords
Efficient Immobilization of Bacterial GH Family 46 Chitosanase by Carbohydrate-Binding Module Fusion for the Controllable Preparation of Chitooligosaccharides.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.9b01608
Abstract: Chitooligosaccharide has been reported to possess diverse bioactivities. The development of novel strategies for obtaining optimum degree of polymerization (DP) chitooligosaccharides has become increasingly important. In this study, two glycoside hydrolase family 46 chitosanases were… read more here.
Keywords: immobilization; carbohydrate binding; family; binding module ... See more keywords
C3-Symmetric Aromatic Core of Griffithsin Is Essential for Potent Anti-HIV Activity.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical biology"
DOI: 10.1021/acschembio.1c00990
Abstract: Lectins, carbohydrate-binding proteins of nonimmune origin, bind to carbohydrates and glycan shields present on the surfaces of cells and viral spike proteins. Lectins thus hold great promise as therapeutic and diagnostic proteins, exemplified by their… read more here.
Keywords: aromatic core; carbohydrate binding; carbohydrate; activity ... See more keywords