An Expeditious Approach for the Synthesis of β‐Carboline−Pyrazole‐Based Molecular Hybrids
Sign Up to like & getrecommendations! Published in 2018 at "Asian Journal of Organic Chemistry"
DOI: 10.1002/ajoc.201700545
Abstract: A simple and highly efficient one-pot metal-free approach has been devised for the synthesis of β-carboline and pyrazole/pyrazoline based molecular hybrids. The synthesis of β-carboline C-1 tethered (N-acetyl)pyrazolines was achieved via cyclo-condensation approach while β-carboline… read more here.
Keywords: carboline pyrazole; based molecular; synthesis carboline; carboline ... See more keywords
Design and synthesis of β-carboline and combretastatin derivatives as anti-neutrophilic inflammatory agents.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.104846
Abstract: A series of β-carboline derivatives was synthesized by the Pictet-Spengler reaction with or without the combretastatin skeleton. The structures of these derivatives were elucidated by spectroscopic techniques. All synthesized compounds were evaluated for their anti-inflammatory… read more here.
Keywords: design synthesis; ntu 228; carboline combretastatin; synthesis carboline ... See more keywords
Synthesis and anti-Mycobacterium tuberculosis activity of imide-β-carboline and carbomethoxy-β-carboline derivatives.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.111935
Abstract: A series of methyl β-carboline carboxylates (2a-g) and of imide-β-carboline derivatives containing the phthalimide (4a-g), maleimide (5b, g) and succinimide (6b, e, g) moiety were synthesized, and evaluated for their activity against Mycobacterium tuberculosis H37Rv.… read more here.
Keywords: carboline derivatives; tuberculosis activity; tuberculosis; carboline ... See more keywords
Structure activity relationship in β-carboline derived anti-malarial agents.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113536
Abstract: Malaria, even though an avoidable and treatable disease, can be fatal if ignored. Artemisinin Combination Therapy (ACT) and RTS, S/AS01 vaccine (Mosquirix™) are the only modest means available with humans to overcome malaria, a lethal… read more here.
Keywords: carboline derived; activity relationship; structure activity; carboline ... See more keywords
Recent evolution on synthesis strategies and anti-leishmanial activity of β-carboline derivatives – An update
Sign Up to like & getrecommendations! Published in 2020 at "Heliyon"
DOI: 10.1016/j.heliyon.2020.e04916
Abstract: Leishmaniasis is the most widespread pathogenic disease in several countries. Currently, no effective vaccines are available, and the control of Leishmaniasis primarily relies on decade-old chemotherapy. The treatment for the Leishmaniasis is not up to… read more here.
Keywords: leishmaniasis; anti leishmanial; carboline; recent evolution ... See more keywords
Characterization of a new microbial Pictet-Spenglerase NscbB affording the β-carboline skeletons from Nocardiopsis synnemataformans DSM 44143.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of biotechnology"
DOI: 10.1016/j.jbiotec.2018.07.007
Abstract: The enzymatic Pictet-Spengler (PS) reaction, catalyzed by Pictet-Spenglerase (PSase), is the feature of β-carboline (βC) alkaloid biosynthesis. NscbB is a rare microbial PSase discovered from a cryptic β-carboline alkaloid biosynthetic gene cluster (BGC) in the… read more here.
Keywords: pictet spenglerase; nocardiopsis synnemataformans; dsm 44143; synnemataformans dsm ... See more keywords
Formation, Characterization, and Occurrence of β-Carboline Alkaloids Derived from α-Dicarbonyl Compounds and l-Tryptophan
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Agricultural and Food Chemistry"
DOI: 10.1021/acs.jafc.2c03187
Abstract: β-Carbolines (βCs) are naturally occurring bioactive alkaloids, whereas α-dicarbonyl compounds are reactive substances generated in foods and in vivo. In this work, l-tryptophan reacted with α-dicarbonyl compounds affording new β-carbolines. Glyoxal afforded 1-hydroxymethyl-β-carboline (HME-βC) and… read more here.
Keywords: carboline; occurrence carboline; characterization occurrence; dicarbonyl compounds ... See more keywords
Orthoscuticellines A-E, β-Carboline Alkaloids from the Bryozoan Orthoscuticella ventricosa Collected in Australia.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.9b00933
Abstract: Antiplasmodial high-throughput screening of extracts derived from marine invertebrates collected from northern NSW, Australia, resulted in the methanol extract of the bryozoan Orthoscuticella ventricosa being identified as inhibitory toward the 3D7 strain of Plasmodium falciparum.… read more here.
Keywords: carboline alkaloids; bryozoan orthoscuticella; carboline; orthoscuticella ventricosa ... See more keywords
Malaria Box-Inspired Discovery of N-Aminoalkyl-β-carboline-3-carboxamides, a Novel Orally Active Class of Antimalarials.
Sign Up to like & getrecommendations! Published in 2022 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.1c00663
Abstract: Virtual ligand screening of a publicly available database of antimalarial hits using a pharmacophore derived from antimalarial MMV008138 identified TCMDC-140230, a tetrahydro-β-carboline amide, as worthy of exploration. All four stereoisomers of this structure were synthesized,… read more here.
Keywords: carboline; discovery aminoalkyl; aminoalkyl carboline; box inspired ... See more keywords
ZnO-NP assisted synthesis of fluorescent β-carboline C-1 tethered benzimidazole/benzothiazole/benzoxazole derivatives and assessment of their photophysical properties
Sign Up to like & getrecommendations! Published in 2019 at "New Journal of Chemistry"
DOI: 10.1039/c9nj04256c
Abstract: A facile transformation of 1-formyl β-carboline into fluorescent β-carboline C-1 tethered benzazole derivatives is described under the catalysis of ZnO nanoparticles. read more here.
Keywords: fluorescent carboline; carboline tethered; carboline; assisted synthesis ... See more keywords
Selectivity-tunable oxidation of tetrahydro-β-carboline over an OMS-2 composite catalyst: preparation and catalytic performance.
Sign Up to like & getrecommendations! Published in 2021 at "Dalton transactions"
DOI: 10.1039/d1dt00168j
Abstract: Controlling the reaction selectivity of organic transformations without losing high conversion is always a challenge in catalytic processes. In this work, a H3PO4·12WO3/OMS-2 nanocomposite catalyst ([PW]-OMS-2) was prepared through the oxidation of a Mn(ii) salt… read more here.
Keywords: composite catalyst; oxidation; tetrahydro; carboline ... See more keywords