Discovery of novel α‐carboline derivatives as glycogen synthase kinase‐3β inhibitors for the treatment of Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200156
Abstract: Alzheimer's disease (AD) is a chronic and progressive neurodegenerative disease, characterized by irreversible cognitive impairment, memory loss, and behavioral disturbances, ultimately resulting in death. The critical roles of glycogen synthase kinase‐3β (GSK‐3β) in tau pathology… read more here.
Keywords: disease; alzheimer disease; carboline derivatives; glycogen synthase ... See more keywords
Synthesis and Assessment of Fused β‐Carboline Derivatives as Kappa Opioid Receptor Agonists
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DOI: 10.1002/cmdc.202100029
Abstract: The synthesis of 5‐formyl‐6‐aryl‐6H‐indolo[3,2,1‐de][1,5] naphthyridine‐2‐carboxylates by reaction between 1‐formyl‐9H‐β‐carbolines and cinnamaldehydes in the presence of pyrrolidine in water with microwave irradiation is described. Pharmacophoric modification of the formyl group offered several new fused β‐carboline derivatives,… read more here.
Keywords: opioid receptor; synthesis assessment; carboline derivatives; assessment fused ... See more keywords
Synthesis and anti-Mycobacterium tuberculosis activity of imide-β-carboline and carbomethoxy-β-carboline derivatives.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.111935
Abstract: A series of methyl β-carboline carboxylates (2a-g) and of imide-β-carboline derivatives containing the phthalimide (4a-g), maleimide (5b, g) and succinimide (6b, e, g) moiety were synthesized, and evaluated for their activity against Mycobacterium tuberculosis H37Rv.… read more here.
Keywords: carboline derivatives; tuberculosis activity; tuberculosis; carboline ... See more keywords
Synthesis and photophysical properties of carboline derivatives and their applications in OLEDs
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Crystals and Liquid Crystals"
DOI: 10.1080/15421406.2017.1338073
Abstract: ABSTRACT Four novel meta-linked carboline derivatives, two δ-carboline-based, 1, 3-bis (5H-pyrido[3,2-b]- indol-5-yl)benzene (mCdP) and 2,6-bis(5H-pyrido[3,2-b]indol-5-yl)pyridine (26mCdPy) were synthesized, as well as two α-carboline derivatives, 1,3-bis(9H-pyrido[2,3-b]indol-9-yl) benzene (mCaP) and 2,6-bis(9H-pyrido[2,3-b]indol-9-yl)pyridine (26mCaPy) as comparison. The triplet energy… read more here.
Keywords: bis pyrido; carboline derivatives; properties carboline; pyrido indol ... See more keywords
Synthesis and Antibacterial Study of Novel Harmine Derivatives and Tetrahydro-β-Carboline Derivatives In Vitro
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27092888
Abstract: Dairy mastitis is a disease of dairy cattle caused by a variety of pathogenic microorganisms which has biought huge economic losses aused huge economic losses to the world. In this paper, Harmine derivatives and tetrahydro-β-carboline… read more here.
Keywords: streptococcus dysgalactiae; tetrahydro carboline; carboline derivatives; derivatives tetrahydro ... See more keywords