Exploiting 3‐Methyleneisoindolinones as In Situ Generated Reactive Intermediates in the Synthesis of Tetrasubstituted Carbon Center
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DOI: 10.1002/ajoc.202500562
Abstract: In this study, we describe the operationally simple construction of a tetrasubstituted carbon center utilizing in situ formation of 3‐methyleneisoindolinones as reactive intermediates. An acid‐catalyzed Meyer–Schuster rearrangement of isoindolinone‐based propargylic alcohols followed by an intermolecular… read more here.
Keywords: exploiting methyleneisoindolinones; carbon center; reactive intermediates; tetrasubstituted carbon ... See more keywords
Enantioselective Dehydroxyhydrogenation of 3-Indolylmethanols by the Combined Use of Benzothiazoline and Chiral Phosphoric Acid: Construction of a Tertiary Carbon Center.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c00430
Abstract: The chiral indole is an important structure in organic chemistry. We have developed an enantioselective hydrogen transfer reaction of indolylmethanol, which is characterized by the combined use of benzothiazoline and a newly synthesized chiral phosphoric… read more here.
Keywords: carbon center; chiral phosphoric; phosphoric acid; tertiary carbon ... See more keywords
Asymmetric Construction of Halogenated Cyclic Quaternary Carbon Center through Enolate Activation of Aldehydes
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DOI: 10.1055/s-0037-1610256
Abstract: The construction of a chiral halogenated cyclic quaternary carbon center through various catalytic strategies is an emerging hot topic in the field of asymmetric synthesis. Herein, we give a summary of recently developed synthetic methods… read more here.
Keywords: cyclic quaternary; carbon center; construction; enolate activation ... See more keywords
A Practical Electrochemical Approach for Synthesizing Selenyl-Dihydrobenzofurans and Chromane with a Tetrasubstituted Carbon Center
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DOI: 10.1055/s-0043-1775373
Abstract: A straightforward and efficient electrochemical method for the anodic oxidative selenenylation of 2-(2-arylallyl)phenols and a 2-(3-arylbut-3-en-1-yl)phenol with diselenides under ambient air conditions has been outlined. This method allows for the synthesis of selenyl-dihydrobenzofurans and a… read more here.
Keywords: selenyl dihydrobenzofurans; carbon center; dihydrobenzofurans chromane; tetrasubstituted carbon ... See more keywords