Catalytic Enantioselective Synthesis of 2,3-Dihydrobenzo[b]oxepines via Asymmetric Oxetane Opening by Internal Carbon Nucleophiles.
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DOI: 10.1021/acs.orglett.1c03852
Abstract: An intramolecular C-C formation process based on catalytic asymmetric oxetane opening by carbon nucleophiles has been developed, which provides rapid access to a range of valuable enantioenriched 2,3-dihydrobenzo[b]oxepines. With the combination of Sc(OTf)3 and a… read more here.
Keywords: carbon nucleophiles; oxetane opening; dihydrobenzo oxepines; asymmetric oxetane ... See more keywords
Copper-Catalyzed Asymmetric Addition of Tertiary Carbon Nucleophiles to 2 H-Azirines: Access to Chiral Aziridines with Vicinal Tetrasubstituted Stereocenters.
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DOI: 10.1021/acs.orglett.8b02274
Abstract: A catalytic asymmetric nucleophilic addition of tertiary carbon nucleophiles to 2 H-azirines was established in the presence of the chiral N,N'-dioxide/CuII complex. Various chiral aziridines with vicinal tetrasubstituted stereocenters were obtained in high yields with… read more here.
Keywords: nucleophiles azirines; carbon nucleophiles; chiral aziridines; tertiary carbon ... See more keywords