Organocatalytic Asymmetric Construction of Tetrasubstituted Carbon Stereocenters Bearing Three Heteroatoms via Intramolecular Cyclization of Vinylidene ortho-Quinone Methide with Imidates.
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DOI: 10.1021/acs.orglett.2c01842
Abstract: We report herein an organocatalytic asymmetric protocol for the construction of tetrasubstituted carbon stereocenters bearing three heteroatoms. The reaction proceeded via the enantioselective intramolecular cyclization reaction of vinylidene ortho-quinone methide (VQM) with imidates to form… read more here.
Keywords: tetrasubstituted carbon; carbon; stereocenters bearing; organocatalytic asymmetric ... See more keywords
Stereospecific Construction of Quaternary Carbon Stereocenters from Quaternary Carbon Stereocenters
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DOI: 10.1021/jacs.2c01695
Abstract: Organoaluminum species promote a smooth nucleophilic substitution at the quaternary carbon stereocenter of stereodefined polysubstituted cyclopropyl methyl phosphate with a complete inversion of configuration, even when more reactive functional groups are present. The regio- and… read more here.
Keywords: carbon; quaternary carbon; carbon stereocenters; stereocenters quaternary ... See more keywords