Palladium-Catalyzed [5 + 2] Annulation of Vinylethylene Carbonates with Barbiturate-Derived Alkenes.
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DOI: 10.1021/acs.orglett.0c02508
Abstract: A palladium/XantPhos-catalyzed [5 + 2] annulation of VECs with electron-deficient alkenes having an isolated carbon-carbon double bond has been developed to afford spirobarbiturate-tetrahydrooxepines. This study provides an expedient assembly of biologically interesting spirobarbiturate-tetrahydrooxepines. The easy… read more here.
Keywords: annulation; vinylethylene carbonates; carbonates barbiturate; palladium catalyzed ... See more keywords