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Published in 2017 at "Geophysical Research Letters"
DOI: 10.1002/2017gl075797
Abstract: This paper describes the quantification of extracellular carbonic anhydrase (eCA) concentrations in the sea surface microlayer (SML), the boundary layer between the ocean and the atmosphere of the Indo-West Pacific. We demonstrated that the SML…
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Keywords:
carbonic anhydrase;
enrichment;
sea;
extracellular carbonic ... See more keywords
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1
Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13376
Abstract: The abnormal lipid metabolism in the liver that occurs after high caloric intake is the main cause of nonalcoholic fatty liver disease (NAFLD). Differences between samples from healthy livers and livers from individuals with NAFLD…
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Keywords:
carbonic anhydrase;
fat accumulation;
accumulation;
expression ... See more keywords
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Published in 2017 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.201700198
Abstract: In the present study, human carbonic anhydrase (hCA) enzyme was purified and characterized from fresh blood human red cells by Sepharose‐4B‐l‐tyrosine‐sulfanilamide affinity gel chromatography. Secondly, a series of new tetrabromo chalcone derivatives containing 4,7‐methanoisoindol‐1,3‐dione (2a–i)…
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Keywords:
carbonic anhydrase;
tetrabromo chalcone;
chalcone derivatives;
inhibition ... See more keywords
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Published in 2018 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.201800029
Abstract: meta‐Cyanobenzyl‐substituted N‐heterocyclic carbene (NHC) precursors were synthesized by the reaction of a series of N‐(alkyl)benzimidazolium with 3‐bromomethyl‐benzonitrile. These benzimidazolium salts were characterized by using 1H NMR, 13C NMR, FTIR spectroscopy, and elemental analysis techniques. The…
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Keywords:
carbonic anhydrase;
meta cyanobenzyl;
benzimidazolium salts;
benzimidazolium ... See more keywords
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1
Published in 2018 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.201800200
Abstract: A series of substituteed pyrazol‐4‐yl‐diazene derivatives were found to be effective inhibitors against α‐glycosidase, cytosolic carbonic anhydrase I and II isoforms (hCA I and II), butyrylcholinesterase (BChE), and acetylcholinesterase (AChE) with Ki values in the…
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Keywords:
carbonic anhydrase;
glycosidase;
derivatives potent;
pyrazoles derivatives ... See more keywords
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Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202100476
Abstract: This paper presents experimental and molecular docking studies on the inhibitory effects of tyrosol, hydroxytyrosol, luteolin, diosmetin, caffeic acid, luteolin 7‐O‐glycoside, and apigenin 7‐O‐glycoside from olive (Olea europaea L.) leaf against human carbonic anhydrase (hCA,…
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Keywords:
anhydrase inhibitors;
carbonic anhydrase;
natural compounds;
compounds carbonic ... See more keywords
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Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200019
Abstract: Saccharin is a cyclic secondary sulfonamide, which is a selective inhibitor of the tumor‐associated carbonic anhydrase (CA; EC 4.2.1.1) enzymes CA IX and CA XII compared to many primary sulfonamides. In this study, new saccharin‐1,2,3‐triazole…
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Keywords:
design synthesis;
carbonic anhydrase;
hca;
hca hca ... See more keywords
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Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200383
Abstract: In recent years, multistep hybrid computational protocols have attracted attention for their application in the drug discovery of enzyme inhibitors. So far, there are large collections of human carbonic anhydrase (hCA) inhibitors, but only a…
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Keywords:
human carbonic;
sulfonamide based;
carbonic anhydrase;
hca ... See more keywords
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Published in 2023 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200562
Abstract: Carbonic anhydrase (CA) is a metalloenzyme that catalyzes the interconversion between carbon dioxide and water and dissociated ions of carbonic acid. In addition, CA performs various other functions in animals and plants, depending on the…
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Keywords:
pyrazoline excellent;
design;
carbonic anhydrase;
pyrazole pyrazoline ... See more keywords
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Published in 2019 at "Journal of Chemometrics"
DOI: 10.1002/cem.3189
Abstract: Cancer is the second leading cause of death worldwide, and breast cancer accounts for 2.09 million cases in the year 2018. Hypoxia‐related human carbonic anhydrase IX enzyme was found to play a key role in…
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Keywords:
carbonic anhydrase;
anhydrase inhibitory;
triazole benzene;
human carbonic ... See more keywords
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1
Published in 2018 at "ChemMedChem"
DOI: 10.1002/cmdc.201800375
Abstract: Pseudomonas aeruginosa is a Gram‐negative facultative anaerobe belonging to the Pseudomonadaceae family. It is a multidrug‐resistant opportunistic human pathogen, a common cause of life‐threatening nosocomial infections, and a key bacterial agent in cystic fibrosis and…
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Keywords:
carbonic anhydrase;
pseudomonas aeruginosa;
structural mapping;
mapping anion ... See more keywords