Experimental and computational approaches to the analysis of the molecular structure of (E)-3-(3-(4-nitrophenyl)triaz-1-en-1-yl)-1H-pyrazole-4-carbonitrile
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2017.11.006
Abstract: Abstract A green, fast and straightforward procedure for the synthesis of ( E )-3-(3-(4-nitrophenyl)triaz-1-en-1-yl)-1 H -pyrazole-4-carbonitrile is described in this paper. The method uses a coupling reaction between 4- nitrophenyl diazonium chloride and 5-aminopyrazole-4-carbonitrile. The… read more here.
Keywords: triaz pyrazole; structure; pyrazole carbonitrile; carbonitrile ... See more keywords
Experimental and theoretical study on the regioselective bis- and polyalkylation of 2-mercaptonicotinonitrile and 2-mercaptopyrimidine-5-carbonitrile derivatives
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DOI: 10.1016/j.tet.2017.01.047
Abstract: The synthetic utility of 2-mercaptonicotinonitriles 3 and 4, as well as 2-mercapto-4-oxo-6-phenyl-1,4-dihydropyrimidine-5-carbonitrile 20 as building blocks for novel bis- and poly(pyridines), along with poly(pyrimidines) via alkylation with the corresponding bis- and poy(halo) compounds was investigated.… read more here.
Keywords: theoretical study; regioselective bis; bis polyalkylation; study regioselective ... See more keywords
Enzyme Sensing Using 2-Mercaptopyridine-Carbonitrile Reporters and Surface-Enhanced Raman Scattering
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DOI: 10.1021/acsomega.2c00139
Abstract: The high sensitivity and functional group selectivity of surface-enhanced Raman scattering (SERS) make it an attractive method for enzyme sensing, but there is currently a severe lack of enzyme substrates that release SERS reporter molecules… read more here.
Keywords: surface enhanced; carbonitrile; mercaptopyridine carbonitrile; mpn ... See more keywords
Copper(II)-mediated formation of oxazole-4-carbonitrile from acetophenone and coordinated cyanide anion via a radical coupling
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DOI: 10.1039/c7ra01983a
Abstract: A protocol for the direct synthesis of 5-aryloxazole-4-carbonitrile from acetophenone was first described with potassium ferricyanide as a cheap and low toxicity cyanide reagent, in which, multiple bond formation was implemented via an oxygen mediated… read more here.
Keywords: mediated formation; copper mediated; carbonitrile; carbonitrile acetophenone ... See more keywords
Synthesis and Evaluation of 68Ga-Labeled (2S,4S)-4-Fluoropyrrolidine-2-Carbonitrile and (4R)-Thiazolidine-4-Carbonitrile Derivatives as Novel Fibroblast Activation Protein-Targeted PET Tracers for Cancer Imaging
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28083481
Abstract: Fibroblast activation protein α (FAP-α) is a cell-surface protein overexpressed on cancer-associated fibroblasts that constitute a substantial component of tumor stroma and drive tumorigenesis. FAP is minimally expressed by most healthy tissues, including normal fibroblasts.… read more here.
Keywords: fluoropyrrolidine carbonitrile; fibroblast activation; carbonitrile; cancer ... See more keywords