Optimization of 2-Amino-4,6-diarylpyrimidine-5-carbonitriles as Potent and Selective A1 Antagonists
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DOI: 10.1021/acs.jmedchem.1c01636
Abstract: We herein document a large collection of 108 2-amino-4,6-disubstituted-pyrimidine derivatives as potent, structurally simple, and highly selective A1AR ligands. The most attractive ligands were confirmed as antagonists of the canonical cyclic adenosine monophosphate pathway, and… read more here.
Keywords: amino diarylpyrimidine; diarylpyrimidine carbonitriles; carbonitriles potent; selective antagonists ... See more keywords