Bioevaluation of quinoline‐4‐carbonyl derivatives of piperazinyl‐benzothiazinones as promising antimycobacterial agents
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200168
Abstract: The quinoline moiety remains a privileged antitubercular (anti‐TB) pharmacophore, whereas 8‐nitrobenzothiazinones are emerging potent antimycobacterial agents with two investigational candidates in the clinical pipeline. Herein, we report the synthesis and bioevaluation of 30 piperazinyl‐benzothiazinone‐based quinoline… read more here.
Keywords: quinoline carbonyl; carbonyl derivatives; bioevaluation quinoline; antimycobacterial agents ... See more keywords
Access to N-Carbonyl Derivatives of Iminosydnones by Carbonylimidazolium Activation.
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DOI: 10.1021/acs.orglett.0c00600
Abstract: A new methodology for N-exocyclic functionalization of iminosydnones was developed involving the addition of a large variety of nucleophiles on carbonyl-imidazolium-activated iminosydnones. This practical and highly versatile method provided access to new classes of iminosydnones… read more here.
Keywords: access carbonyl; carbonylimidazolium activation; carbonyl derivatives; iminosydnones carbonylimidazolium ... See more keywords
Manganese(I)-Catalyzed Asymmetric Hydrophosphination of α,β-Unsaturated Carbonyl Derivatives
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DOI: 10.1021/acs.orglett.2c04256
Abstract: Here we report catalytic asymmetric hydrophosphination of α,β-unsaturated carbonyl derivatives using a chiral Mn(I) complex as a catalyst. Through H–P bond activation, various phosphine-containing chiral products can be accessed via hydrophosphination of various ketone-, ester-,… read more here.
Keywords: manganese catalyzed; unsaturated carbonyl; asymmetric hydrophosphination; hydrophosphination ... See more keywords
Transfer Hydrogenation of Carbonyl Derivatives Catalyzed by an Inexpensive Phosphine-Free Manganese Precatalyst.
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DOI: 10.1021/acs.orglett.7b01657
Abstract: A very simple and inexpensive catalytic system based on abundant manganese as transition metal and on an inexpensive phosphine-free bidendate ligand, 2-(aminomethyl)pyridine, has been developed for the reduction of a large variety of carbonyl derivatives… read more here.
Keywords: transfer hydrogenation; inexpensive phosphine; carbonyl derivatives; phosphine free ... See more keywords
Asymmetric synthesis of cyclic β-amino carbonyl derivatives by a formal [3 + 2] photocycloaddition.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d1cc05867c
Abstract: Herein, a visible-light mediated strategy unlocking a family of cyclic β-amino carbonyl derivatives bearing three contiguous stereogenic centres is introduced. The overall reactivity relies on the performance of the substrate-catalyst complex to assist both the… read more here.
Keywords: cyclic amino; amino carbonyl; carbonyl derivatives;