Transcription of carbonyl reductase 1 is regulated by DNA topoisomerase II beta
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Letters"
DOI: 10.1002/1873-3468.13904
Abstract: DNA topoisomerase II beta (TOP2B) has a role in transcriptional regulation. Here, to further investigate transcriptional regulation by TOP2B, we used RNA‐sequencing and real‐time PCR to analyse the differential gene expression profiles of wild‐type and… read more here.
Keywords: dna topoisomerase; topoisomerase beta; carbonyl reductase;
Engineering a Carbonyl Reductase as a Potential Tool for the Synthesis of Chiral α‐Tetralinols
Sign Up to like & getrecommendations! Published in 2021 at "ChemCatChem"
DOI: 10.1002/cctc.202100890
Abstract: Tailoring of enzyme toward α‐tetralones, a class of bulky‐bulky ketones, is still a challenge. In this work, the mutants of carbonyl reductase BaSDR1 with improved catalytic performance toward α‐tetralone 1 a were obtained by adjusting the… read more here.
Keywords: tetralone; potential tool; carbonyl reductase; engineering ... See more keywords
Dehydrogenase/reductase activity of human carbonyl reductase 1 with NADP(H) acting as a prosthetic group.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.11.090
Abstract: Carbonyl reductase 1 (CBR1) is an NADP-dependent enzyme that exerts a detoxifying role, which catalyses the transformation of carbonyl-containing compounds. The ability of CBR1 to act on adducts between glutathione and lipid peroxidation derived aldehydes… read more here.
Keywords: reductase; prosthetic group; carbonyl reductase; cbr1 ... See more keywords
Enzymatic synthesis of an ezetimibe intermediate using carbonyl reductase coupled with glucose dehydrogenase in an aqueous-organic solvent system.
Sign Up to like & getrecommendations! Published in 2017 at "Bioresource technology"
DOI: 10.1016/j.biortech.2016.12.098
Abstract: (4S)-3-[(5S)-5-(4-Fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one ((S)-ET-5) is an important chiral intermediate in the synthesis of chiral side chain of ezetimibe. Recombinant Escherichia coli expressing carbonyl reductase (CBR) was successfully constructed in this study. The total E. coli biomass and… read more here.
Keywords: solvent system; aqueous organic; ezetimibe; carbonyl reductase ... See more keywords
Potent inhibition of human carbonyl reductase 1 (CBR1) by the prenylated chalconoid xanthohumol and its related prenylflavonoids isoxanthohumol and 8-prenylnaringenin.
Sign Up to like & getrecommendations! Published in 2019 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2019.02.031
Abstract: In terms of drug disposal and metabolism SDR21C1 (carbonyl reductase 1; CBR1) exerts an assorted substrate spectrum among a large variety of clinically relevant substances. Additionally, this short-chain dehydrogenase/reductase is extensively expressed in most tissues… read more here.
Keywords: reductase; reductase cbr1; isoxanthohumol prenylnaringenin; carbonyl reductase ... See more keywords
Improvement of operational stability of Ogataea minuta carbonyl reductase for chiral alcohol production.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of bioscience and bioengineering"
DOI: 10.1016/j.jbiosc.2017.01.016
Abstract: Directed evolution of enantio-selective carbonyl reductase from Ogataea minuta was conducted to improve the operational stability of the enzyme. A mutant library was constructed by an error-prone PCR and screened using a newly developed colorimetric… read more here.
Keywords: stability; operational stability; carbonyl reductase; ogataea minuta ... See more keywords
Expression of engineered carbonyl reductase from Ogataea minuta in Rhodococcus opacus and its application to whole-cell bioconversion in anhydrous solvents.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of bioscience and bioengineering"
DOI: 10.1016/j.jbiosc.2018.07.011
Abstract: The carbonyl reductase from the methylotrophic yeast Ogataea minuta can catalyze the regio- and enantio-selective reduction of prochiral ketones to chiral alcohols, and is available for industrial manufacturing of statin drugs. We previously conducted a… read more here.
Keywords: bioconversion; organic solvents; whole cell; carbonyl reductase ... See more keywords
Significantly enhancing the biocatalytic synthesis of chiral alcohols by semi-rationally engineering an anti-Prelog carbonyl reductase from Acetobacter sp. CCTCC M209061
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Catalysis"
DOI: 10.1016/j.mcat.2019.110613
Abstract: Abstract Chiral alcohols and their derivatives are vital building blocks to synthesize pharmaceutical drugs and high-valued chemicals. Wild-type carbonyl reductase AcCR from Acetobacter sp. has ideal enantioselectivity toward 11 prochiral substrates (e.e.>99%) but poor activity.… read more here.
Keywords: synthesis chiral; acetobacter; carbonyl reductase; chiral alcohols ... See more keywords
LncRNA MYMLR promotes pituitary adenoma development by upregulating carbonyl reductase 1 via sponging miR-197-3p
Sign Up to like & getrecommendations! Published in 2022 at "Anti-Cancer Drugs"
DOI: 10.1097/cad.0000000000001385
Abstract: Long noncoding RNAs (lncRNAs) have been demonstrated to participate in various biological processes and play key roles in tumorigenesis and metastasis. Pituitary adenoma (PA) is one of the most common malignancies in central nervous system.… read more here.
Keywords: pituitary adenoma; development; carbonyl reductase; mir 197 ... See more keywords
Identification and Characterization of a Selective Human Carbonyl Reductase 1 Substrate
Sign Up to like & getrecommendations! Published in 2018 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.118.082487
Abstract: During drug discovery efforts targeting inhibition of cytochrome P450 11B2 (CYP11B2)–mediated production of aldosterone as a therapeutic approach for the treatment of chronic kidney disease and hypertension, (S)-6-(5-fluoro-4-(1-hydroxyethyl)pyridin-3-yl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide (1) was identified as a potent and… read more here.
Keywords: identification; carbonyl reductase; identification characterization;
Inhibitory Effect of Fruit Juices on the Doxorubicin Metabolizing Activity of Carbonyl Reductase 1.
Sign Up to like & getrecommendations! Published in 2017 at "Drug metabolism letters"
DOI: 10.2174/1872312811666170309153025
Abstract: BACKGROUND AND OBJECTIVE Doxorubicin, an anthracycline anti-cancer drug, is effective for breast cancer and childhood lymphoma. Chronic cardiotoxicity has been known as a critical adverse effect of doxorubicin and is attributed to its metabolite doxorubicinol… read more here.
Keywords: fruit; fruit juices; effect; carbonyl reductase ... See more keywords