Glyoxalase I disruption and external carbonyl stress impair mitochondrial function in human induced pluripotent stem cells and derived neurons
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DOI: 10.1038/s41398-021-01392-w
Abstract: Carbonyl stress, a specific form of oxidative stress, is reported to be involved in the pathophysiology of schizophrenia; however, little is known regarding the underlying mechanism. Here, we found that disruption of GLO1 , the… read more here.
Keywords: external carbonyl; human induced; derived neurons; stress ... See more keywords
Pyridoxamine: A novel treatment for schizophrenia with enhanced carbonyl stress
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DOI: 10.1111/pcn.12613
Abstract: The aim of this clinical trial was to obtain proof of concept for high‐dose pyridoxamine as a novel treatment for schizophrenia with enhanced carbonyl stress. read more here.
Keywords: novel treatment; schizophrenia enhanced; enhanced carbonyl; treatment schizophrenia ... See more keywords
Enhanced carbonyl stress induces irreversible multimerization of CRMP2 in schizophrenia pathogenesis
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DOI: 10.26508/lsa.201900478
Abstract: Enhanced carbonyl stress results in neurodevelopmental deficits by affecting microtubule function through the formation of irreversible dysfunctional multimer of carbonylated CRMP2. Enhanced carbonyl stress underlies a subset of schizophrenia, but its causal effects remain elusive.… read more here.
Keywords: schizophrenia; stress; enhanced carbonyl; carbonylated crmp2 ... See more keywords