A Regioselective Approach to Trisubstituted Pyrazoles via Palladium-Catalyzed Oxidative Sonogashira-Carbonylation of Arylhydrazines.
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DOI: 10.1021/acs.orglett.7b01447
Abstract: A palladium-catalyzed oxidative carbonylation of arylhydrazines and alkynes with balloon pressure CO/O2 to afford trisubstituted pyrazoles in a one-pot manner has been developed. The formation of trisubstituted pyrazoles involves a sequential C-N bond cleavage, carbonylation,… read more here.
Keywords: trisubstituted pyrazoles; carbonylation; palladium catalyzed; carbonylation arylhydrazines ... See more keywords